Protein detail

CUED1

CUE domain-containing protein 1

Entry name CUED1	UniProt ID Q9NWM3	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

CUE domain-containing protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000180891

Entrez Gene Symbol

CUEDC1

Gene Description

CUE domain containing 1

Chromosome

Position

57861243-57955412

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificOocytes

Function & Pathway3

Protein Function

Predicted intracellular proteins

Molecular Function (2)

Mediation Categories

Other mediation

Relations & Evidence4

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster279	CUEDC1 TOM1 TOM1L2	O60784 Q6ZVM7 Q9NWM3	1:1:1	Compleat	Compleat:HC1087	22036573

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass SpectrometryElisaImmunoelectron Microscopy	2	35294531 39940923

Sequence, Structure & Domains11

Sequences

Length

386

Mass

42,258

Sequence

MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NWM3-1; Sequence=Displayed; Name=2; IsoId=Q9NWM3-2; Sequence=VSP_010316

Alternative Sequence

233..260; Missing (in isoform 2)

3D Structural Models

Helix

48..57; 63..73; 77..89

Beta Strand

59..61

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

1..10; Low complexity; 11..27; Gly residues; 199..209; Gly residues

Domain (FT)

46..89; CUE

Region

1..40; Disordered; 147..172; Disordered; 195..225; Disordered; 367..386; Disordered

Clinical Relevance4

Antibody (2)

HPA023050 HPA024836

Interaction Protein (2)

ENSG00000108854ENSG00000188906

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
28369848	End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.	No abstract available
35551477	Realistic biomarkers from plasma extracellular vesicles for detection of beryllium exposure.	No abstract available