Protein detail
CLC5A
C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)
Protein symbol CLC5A | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)
Protein Function
Predicted intracellular proteins
Transmembrane
5..27; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Reactome
- R-hsa-2172127 dap12 interactions
- R-hsa-9920588 dengue virus activates modulates innate and adaptive immune responses
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
188
Mass
21,521
Sequence
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY25-1; Sequence=Displayed; Name=2; IsoId=Q9NY25-2; Sequence=VSP_012839
Alternative Sequence
116; Missing (in isoform 2)
3D Structural Models
Turn
101..103; 135..137; 143..145
Helix
92..100; 112..122
Beta Strand
76..78; 81..85; 127..133; 138..142; 152..154; 161..173; 179..186
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
78..184; C-type lectin