Protein detail
CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]
Protein symbol CA2D2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesFDA approved drug targetsPredicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]
Protein Class
Disease related genesFDA approved drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Disease related genes
- Predicted intracellular proteins
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Transmembrane
1114..1134; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
alpha2delta-2KIAA0558
Gene Description
Calcium voltage-gated channel auxiliary subunit alpha2delta 2
Chromosome
3
Position
50362613-50504244
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificBergmann gliaSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificmemory CD8 T-cellBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
- R-hsa-400042 adrenaline noradrenaline inhibits insulin secretion
- R-hsa-5576891 cardiac conduction
- R-hsa-163685 integration of energy metabolism
- R-hsa-397014 muscle contraction
- R-hsa-112316 neuronal system
- R-hsa-5576892 phase 0 rapid depolarisation
- R-hsa-5576893 phase 2 plateau phase
- R-hsa-112308 presynaptic depolarization and calcium channel opening
- R-hsa-422356 regulation of insulin secretion
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-112315 transmission across chemical synapses
Canonical Pathways
- M55 Pid s1p s1p3 pathway
- M257 Pid ephrinb rev pathway
- M165 Pid syndecan 4 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Cav1.1 voltage-gated calcium channel complexCACNA2D2-CACNB1-CACNG1 variant | CACNA1SCACNA2D2CACNB1CACNG1 | Q02641Q06432Q13698Q9NY47 | 1:1:1:2 | ComplexPortal | intact:EBI-48446603 | 151111041868823527273705147552922668020216382099 |
| Cav1.1 voltage-gated calcium channel complexCACNA2D2-CACNB2-CACNG1 variant | CACNA1SCACNA2D2CACNB2CACNG1 | Q06432Q08289Q13698Q9NY47 | 1:1:1:2 | ComplexPortal | intact:EBI-48446747 | 151111041868823527273705147552922668020216382099 |
| Cav1.1 voltage-gated calcium channel complexCACNA2D2-CACNB3-CACNG1 variant | CACNA1SCACNA2D2CACNB3CACNG1 | P54284Q06432Q13698Q9NY47 | 1:1:1:2 | ComplexPortal | intact:EBI-48446832 | 151111041868823527273705147552922668020216382099 |
| Cav1.1 voltage-gated calcium channel complexCACNA2D2-CACNB4-CACNG1 variant | CACNA1SCACNA2D2CACNB4CACNG1 | O00305Q06432Q13698Q9NY47 | 1:1:1:2 | ComplexPortal | intact:EBI-48446905 | 151111041868823527273705147552922668020216382099 |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
1,150
Mass
129,817
Sequence
MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha2delta-2a; IsoId=Q9NY47-1; Sequence=Displayed; Name=2; Synonyms=Alpha2delta-2b; IsoId=Q9NY47-2; Sequence=VSP_028059; Name=3; IsoId=Q9NY47-3; Sequence=VSP_028059, VSP_028060; Name=4; IsoId=Q9NY47-4; Sequence=VSP_028058, VSP_028059, VSP_028060; Name=5; Synonyms=Alpha2delta-2c; IsoId=Q9NY47-5; Sequence=VSP_028060
Alternative Sequence
1..69; Missing (in isoform 4); 662..669; LPISKLKD -> Y (in isoform 2, isoform 3 and isoform 4); 1076..1077; HS -> HCPA (in isoform 3, isoform 4 and isoform 5)
3D Structural Models
Domain & Motif Annotations
Motif
297..301; MIDAS-like motif
Domain (CC)
The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
Domain (FT)
291..469; VWFA; 485..574; Cache
Region
1..41; Disordered
Protein Families
Calcium channel subunit alpha-2/delta family
Sequence Similarities
Belongs to the calcium channel subunit alpha-2/delta family.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
Antibody