Protein detail
SNTG2
Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5)
Entry name SNTG2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
G2SYNSYN5
Gene Description
Syntrophin gamma 2
Chromosome
2
Position
950849-1367613
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Cell SpecificColonocytesSingle-Nuclei Brain SpecificpericyteBlood Cell Specificnon-classical monocyteBlood Lineage Specificmonocytes
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (5)
Reactome (3)
Mediation Categories
Other mediation
Relations & Evidence9
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains15
Sequences
Length
539
Mass
60,217
Sequence
MGTEGPPPPAASRGRQGCLLVPARTKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVVCVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHMGWVNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIETKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDSQSLARKYMYSS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY99-1; Sequence=Displayed; Name=2; IsoId=Q9NY99-2; Sequence=VSP_039175
Alternative Sequence
71..197; Missing (in isoform 2)
3D Structural Models
Turn
80..82
Helix
92..94; 108..112; 134..142
Beta Strand
72..77; 86..91; 96..103; 120..124; 146..153
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
168..183; Low complexity; 194..205; Low complexity
Domain (CC)
The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
Domain (FT)
73..156; PDZ; 296..421; PH
Region
168..209; Disordered
Protein Families
Syntrophin family
Sequence Similarities
Belongs to the syntrophin family.
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39535266 | Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts. | No abstract available |