Protein detail

CELR1

Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)

Protein symbol CELR1	UniProt ID Q9NYQ6	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Transmembrane

2470..2490; Helical; Name=1; 2502..2522; Helical; Name=2; 2528..2548; Helical; Name=3; 2573..2593; Helical; Name=4; 2612..2632; Helical; Name=5; 2656..2676; Helical; Name=6; 2684..2704; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000075275

Entrez Gene Symbol

CELSR1

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificEpicardial cellsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Mediation Categories

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PLK1	P53350	CELR1	Q9NYQ6	Yes	No	Yes	SIGNOR	SIGNOR:26004507

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CELSR1	Q9NYQ6	2	PDB	PDB:8d40PDB:7sz8

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	40465195 36736734 37322475 38014595 27821849 32230970

Sequence, Structure & Domains

Sequences

Length

3,014

Mass

329,486

Sequence

MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVRTGSAQADGSDSEKP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYQ6-1; Sequence=Displayed; Name=2; IsoId=Q9NYQ6-2; Sequence=VSP_002011, VSP_002012

Alternative Sequence

1395..1397; GEH -> EIS (in isoform 2); 1398..3014; Missing (in isoform 2)

3D Structural Models

Turn

634..636; 647..649; 752..754; 839..841; 852..854; 937..940; 945..947; 958..960

Helix

729..731; 819..822; 922..924

Beta Strand

564..575; 583..586; 600..605; 630..632; 638..641; 651..661; 668..678; 686..690; 692..697; 705..709; 721..726; 733..737; 742..746; 756..768; 770..780; 788..790; 792..799; 807..810; 825..830; 835..837; 843..846; 856..865; 873..883; 891..902; 910..913; 927..935; 941..943; 949..952; 962..972; 975..977; 980..990

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

211..222; Pro residues; 2300..2316; Low complexity; 2796..2806; Basic and acidic residues; 2814..2825; Low complexity; 2876..2904; Basic and acidic residues; 2960..2969; Low complexity; 2983..2992; Basic and acidic residues

Domain (FT)

246..353; Cadherin 1; 354..459; Cadherin 2; 460..565; Cadherin 3; 566..687; Cadherin 4; 688..789; Cadherin 5; 790..892; Cadherin 6; 893..999; Cadherin 7; 1000..1101; Cadherin 8; 1106..1224; Cadherin 9; 1303..1361; EGF-like 1; calcium-binding; 1363..1399; EGF-like 2; calcium-binding; 1403..1441; EGF-like 3; calcium-binding; 1442..1646; Laminin G-like 1; 1649..1685; EGF-like 4; calcium-binding; 1689..1870; Laminin G-like 2; 1872..1907; EGF-like 5; calcium-binding; 1908..1946; EGF-like 6; calcium-binding; 1947..1979; EGF-like 7; calcium-binding; 1981..2016; EGF-like 8; calcium-binding; 2003..2050; Laminin EGF-like; 2297..2461; GAIN-B

Region

205..242; Disordered; 2291..2328; Disordered; 2411..2461; GPS; 2777..2939; Disordered; 2954..3014; Disordered

Protein Families

G-protein coupled receptor 2 family
LN-TM7 subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Clinical Relevance