Protein detail
ITSN2
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Protein symbol ITSN2 | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1256PRO2015SH3D1BSH3P18SWASWAP
Gene Description
Intersectin 2
Chromosome
2
Position
24202864-24360536
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificliverCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Reactome
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-199991 membrane trafficking
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITSN2 | EGFR | P00533 | Y | 553 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15951569 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
1,697
Mass
193,461
Sequence
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=ITSN2-L; IsoId=Q9NZM3-1; Sequence=Displayed; Name=2; IsoId=Q9NZM3-2; Sequence=VSP_003892; Name=3; Synonyms=ITSN2-S1; IsoId=Q9NZM3-3; Sequence=VSP_003893, VSP_003894; Name=4; Synonyms=ITSN2-S2, SH3P18; IsoId=Q9NZM3-4; Sequence=VSP_003895
Alternative Sequence
622..648; Missing (in isoform 2); 1193..1697; Missing (in isoform 4); 1235..1249; FQKRMAESGFLTEGE -> RRLLLASSRGICCLS (in isoform 3); 1250..1697; Missing (in isoform 3)
3D Structural Models
Turn
1336..1340; 1627..1629
Helix
948..950; 1031..1033; 1207..1234; 1236..1242; 1247..1254; 1257..1272; 1288..1294; 1299..1321; 1323..1333; 1343..1346; 1349..1366; 1375..1393; 1655..1665
Beta Strand
762..766; 772..774; 783..786; 793..801; 804..809; 812..815; 818..821; 901..907; 924..931; 934..939; 942..947; 951..954; 983..987; 995..999; 1007..1010; 1012..1014; 1017..1020; 1027..1029; 1056..1060; 1079..1085; 1087..1095; 1104..1108; 1111..1114; 1129..1136; 1153..1156; 1161..1166; 1168..1171; 1180..1183; 1243..1245; 1569..1580; 1592..1598; 1601..1604; 1615..1625; 1631..1638; 1641..1644; 1647..1654; 1670..1673; 1675..1679; 1681..1690
3D Structure
NMR spectroscopy (5); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
219..230; Low complexity
Coiled Coil
361..756
Domain (FT)
22..110; EH 1; 54..89; EF-hand 1; 244..333; EH 2; 277..312; EF-hand 2; 757..818; SH3 1; 898..956; SH3 2; 981..1039; SH3 3; 1053..1117; SH3 4; 1127..1186; SH3 5; 1209..1395; DH; 1434..1544; PH; 1552..1668; C2
Region
219..241; Disordered; 350..378; Disordered; 691..752; Disordered
Clinical Relevance
Antibody
Interaction Protein
ENSG00000127527ENSG00000146648
Interaction Count
2
Interaction Dataset
intact_biogrid_opencellintact_biogrid