Protein detail
EHD3
EH domain-containing protein 3 (PAST homolog 3)
Protein symbol EHD3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
EH domain-containing protein 3 (PAST homolog 3)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PAST3
Gene Description
EH domain containing 3
Chromosome
2
Position
31234152-31269451
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0010008 endosome membrane
- GO:0020018 ciliary pocket membrane
- GO:0030139 endocytic vesicle
- GO:0048471 perinuclear region of cytoplasm
- GO:0055038 recycling endosome membrane
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M151 Pid ar tf pathway
- M58 Pid ar pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACOT13EHD3HDDC3RBSNSSBP1STX16VPS45 | O14662Q04837Q8N4P3Q9H1K0Q9NPJ3Q9NRW7Q9NZN3 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| ACOT13EHD3HDDC3RBSNSTX16VPS45 | O14662Q8N4P3Q9H1K0Q9NPJ3Q9NRW7Q9NZN3 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ACOT13EHD3RBSNSTX16VPS45 | O14662Q9H1K0Q9NPJ3Q9NRW7Q9NZN3 | 0:0:0:0:0 | hu.MAP2 | |||
| EHD3RBSNSTX16VPS45 | O14662Q9H1K0Q9NRW7Q9NZN3 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Flow cytometry | 1 | 35611462 |
Sequence, Structure & Domains
Sequences
Length
535
Mass
60,887
Sequence
MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZN3-1; Sequence=Displayed; Name=2; IsoId=Q9NZN3-2; Sequence=VSP_056606, VSP_056607
Alternative Sequence
169..175; YDFAAVL -> PAAGPGL (in isoform 2); 176..535; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Coiled Coil
198..227
Domain (CC)
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain (FT)
55..286; Dynamin-type G; 444..532; EH; 476..511; EF-hand
Region
65..72; G1 motif; 91..92; G2 motif; 153..156; G3 motif; 219..222; G4 motif; 243; G5 motif
Protein Families
- TRAFAC class dynamin-like GTPase superfamily
- Dynamin/Fzo/YdjA family
- EHD subfamily
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.