Protein detail
EHD2
EH domain-containing protein 2 (PAST homolog 2)
Protein symbol EHD2 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
EH domain-containing protein 2 (PAST homolog 2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PAST2
Gene Description
EH domain containing 2
Chromosome
19
Position
47713422-47743134
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0010008 endosome membrane
- GO:0015630 microtubule cytoskeleton
- GO:0016020 membrane
- GO:0030139 endocytic vesicle
- GO:0045171 intercellular bridge
- GO:0048471 perinuclear region of cytoplasm
- GO:0055038 recycling endosome membrane
- GO:0070062 extracellular exosome
Molecular Function
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryWestern blottingR SequencingFlow cytometryMORPH | 25 | 37862381384411693994949040928027327954142476923323585444245051142924238032295833337095104061999530975894366354003849095841201090307605383132059141216884400914553158823838136601331147683045137138564289 |
Sequence, Structure & Domains
Sequences
Length
543
Mass
61,161
Sequence
MFSWLKRGGARGQQPEAIRTVTSALKELYRTKLLPLEEHYRFGAFHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGDTEGTVPGNALVVDPDKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVGVQGGAFEGTHMGPFVERGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRRHKGSAE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZN4-1; Sequence=Displayed; Name=2; IsoId=Q9NZN4-2; Sequence=VSP_056212
Alternative Sequence
1..136; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
534..543; Basic residues
Motif
120..122; KPF loop; caveolar targeting
Domain (CC)
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain (FT)
55..286; Dynamin-type G; 449..537; EH; 481..516; EF-hand
Region
65..72; G1 motif; 91..92; G2 motif; 153..156; G3 motif; 219..222; G4 motif; 243; G5 motif; 320..340; Mediates membrane-binding; 523..543; Disordered
Protein Families
- TRAFAC class dynamin-like GTPase superfamily
- Dynamin/Fzo/YdjA family
- EHD subfamily
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.