Protein detail
ARHGC
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Protein symbol ARHGC | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count | Protein classification Cancer-related genesDisease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Protein Class
Cancer-related genesDisease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Cancer-related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0382LARG
Gene Description
Rho guanine nucleotide exchange factor 12
Chromosome
11
Position
120336413-120489937
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificEarly spermatids
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Cancer-related genes
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04625 C-type lectin receptor signaling pathway
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-9675108 nervous system development
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-416572 sema4d induced cell migration and growth cone collapse
- R-hsa-400685 sema4d in semaphorin signaling
- R-hsa-373755 semaphorin interactions
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARHGEF12 | RPS6KA3 | P51812 | S | 1,288 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29279389 |
| ARHGEF12 | CDK1 | P06493 | S | 341 | phosphorylation | KEA | KEA:17570479 |
| ARHGEF12 | GSK3B | P49841 | S | 341 | phosphorylation | KEA | KEA:17570479 |
| ARHGEF12 | MAPK14 | Q16539 | S | 341 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GNA13 | Q14344 | ARHGC | Q9NZN5 | Yes | Yes | No | KEGG-MEDICUSSIGNORHPRDBioGRIDWang | HPRD:12515866HPRD:11094164SIGNOR:12024019BioGRID:11094164 |
| FAK1 | Q05397 | ARHGC | Q9NZN5 | Yes | Yes | No | SIGNOR | SIGNOR:19273616 |
| GNA12 | Q03113 | ARHGC | Q9NZN5 | Yes | Yes | No | KEGG-MEDICUSHPRDWangSIGNOR | HPRD:12515866HPRD:11094164SIGNOR:12024019 |
| GNAQ | P50148 | ARHGC | Q9NZN5 | Yes | Yes | No | KEGG-MEDICUSSIGNOR | SIGNOR:12024019 |
| ARHGC | Q9NZN5 | RHOA | P61586 | Yes | Yes | No | WangAdhesomeKEGG-MEDICUSSIGNORHPRDHINTBioGRIDACSNIntActSPIKE_LCLit-BM-17 | Lit-BM-17:20300064SIGNOR:11094164SPIKE_LC:17145710Adhesome:23405219ACSN:11149925ACSN:9641915Adhesome:11373293HINT:15364580IntAct:20300064HINT:32203420SIGNOR:32203420HINT:20300064HINT:15331592Lit-BM-17:23405219Adhesome:20300064ACSN:9789025Adhesome:10592173Adhesome:15364580HPRD:11373293BioGRID:11373293HINT:11373293IntAct:15364580HINT:12515866HINT:33961781Adhesome:12515866ACSN:9113980HINT:34591642Lit-BM-17:11373293Lit-BM-17:15364580 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 29635386 |
Sequence, Structure & Domains
Sequences
Length
1,544
Mass
173,232
Sequence
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQPMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQSQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZN5-1; Sequence=Displayed; Name=2; IsoId=Q9NZN5-2; Sequence=VSP_008131
Alternative Sequence
48..66; Missing (in isoform 2)
3D Structural Models
Turn
122..124
Helix
102..106; 127..135; 769..772; 775..778; 783..812; 814..820; 825..832; 835..853; 865..872; 875..889; 891..904; 906..917; 919..921; 926..929; 932..949; 954..993; 1005..1007; 1008..1011; 1015..1017; 1082..1084; 1117..1137
Beta Strand
70..76; 85..87; 89..91; 93..96; 112..119; 137..145; 857..860; 1001..1003; 1020..1033; 1038..1053; 1056..1058; 1078..1081; 1085..1089; 1091..1093; 1096..1102; 1107..1113
3D Structure
NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
28..45; Basic and acidic residues; 249..260; Polar residues; 293..309; Polar residues; 313..329; Basic and acidic residues; 330..344; Polar residues; 582..592; Basic and acidic residues; 631..640; Polar residues; 663..676; Low complexity; 1138..1149; Polar residues
Coiled Coil
194..262
Domain (FT)
72..151; PDZ; 367..558; RGSL; 787..977; DH; 1019..1132; PH
Region
1..62; Disordered; 247..346; Disordered; 570..706; Disordered; 1138..1179; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genesProto-oncogene
Interaction Protein
ENSG00000067560ENSG00000101558ENSG00000123159ENSG00000124164ENSG00000132694ENSG00000140443ENSG00000177189ENSG00000196586
Interaction Count
8
Interaction Dataset
intact_biogridbiogrid_opencellintact_biogrid_opencell