Protein detail
PD1L1
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Entry name PD1L1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- CD markers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
239..259; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
B7-HB7-H1B7H1PD-L1PDCD1LG1PDL1
Gene Description
CD274 molecule
Chromosome
9
Position
5450503-5470566
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- CD markers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-9931269 ampk induced erad and lysosome mediated degradation of pd l1 cd274
- R-hsa-389948 co inhibition by pd 1
- R-hsa-9929356 gsk3b mediated proteasomal degradation of pd l1 cd274
- R-hsa-9931295 pd l1 cd274 glycosylation and translocation to plasma membrane
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909615 regulation of pd l1 cd274 post translational modification
- R-hsa-9909649 regulation of pd l1 cd274 transcription
- R-hsa-9909620 regulation of pd l1 cd274 translation
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-201556 signaling by alk
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9929491 spop mediated proteasomal degradation of pd l1 cd274
- R-hsa-9701898 stat3 nuclear events downstream of alk signaling
Canonical Pathways
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD274 | PRKAA1 | Q13131 | S | 283 | phosphorylation | PhosphoSite | |
| CD274 | PRKAA1 | Q13131 | S | 195 | phosphorylation | PhosphoSite | |
| CD274 | JAK1 | P23458 | Y | 112 | phosphorylation | PhosphoSite | |
| CD274 | GSK3B | P49841 | S | 184 | phosphorylation | PhosphoSite | |
| CD274 | GSK3B | P49841 | T | 180 | phosphorylation | PhosphoSite | |
| CD274 | PRKAA2 | P54646 | S | 283 | phosphorylation | PhosphoSite | |
| CD274 | GSK3A | P49840 | S | 279 | phosphorylation | PhosphoSite | |
| CD274 | GSK3A | P49840 | S | 283 | phosphorylation | PhosphoSite | |
| CD274 | NEK2 | P51955 | T | 194 | phosphorylation | PhosphoSite | |
| CD274 | NEK2 | P51955 | T | 210 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| b7_family | cell_surface_ligand | HGNC | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
Regulatory Interaction Network
19 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GSK3B | P49841 | PD1L1 | Q9NZQ7 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:33879767PhosphoSite:27572267SIGNOR:27572267 |
| STT3A | P46977 | PD1L1 | Q9NZQ7 | Yes | Yes | No | SIGNOR | SIGNOR:29765039 |
| GSK3A | P49840 | PD1L1 | Q9NZQ7 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapper | ProtMapper:33879767SIGNOR:33879767 |
| CSN5 | Q92905 | PD1L1 | Q9NZQ7 | Yes | Yes | No | HINTSIGNORBioGRID | HINT:31802034SIGNOR:27866850HINT:35114597BioGRID:35114597 |
| FKBP5 | Q13451 | PD1L1 | Q9NZQ7 | Yes | Yes | No | SIGNOR | SIGNOR:28978117 |
| NEK2 | P51955 | PD1L1 | Q9NZQ7 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:34315872SIGNOR:34315872ProtMapper:34315872 |
| B3GN3 | Q9Y2A9 | PD1L1 | Q9NZQ7 | Yes | Yes | No | SIGNOR | SIGNOR:29438695 |
| ITCH | Q96J02 | PD1L1 | Q9NZQ7 | Yes | No | Yes | SIGNOR | SIGNOR:35638972 |
| STT3B | Q8TCJ2 | PD1L1 | Q9NZQ7 | Yes | Yes | No | SIGNOR | SIGNOR:29765039 |
| CKLF6 | Q9NX76 | PD1L1 | Q9NZQ7 | Yes | Yes | No | HINTSIGNORIntAct | IntAct:28813417IntAct:28813410HINT:28813410HINT:28813417SIGNOR:28813410 |
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Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 0 |
Sequence, Structure & Domains
Sequences
Length
290
Mass
33,275
Sequence
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PD-L1I; IsoId=Q9NZQ7-1; Sequence=Displayed; Name=2; Synonyms=PD-L1II; IsoId=Q9NZQ7-2; Sequence=VSP_013735; Name=3; IsoId=Q9NZQ7-3; Sequence=VSP_013736, VSP_013737; Name=4; Synonyms=secPD-L1; IsoId=Q9NZQ7-4; Sequence=VSP_061953
Alternative Sequence
19..132; Missing (in isoform 2); 178; K -> D (in isoform 3); 179..290; Missing (in isoform 3); 228..289; ELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEE -> GNILNVSIKICLTLSPS (in isoform 4)
3D Structural Models
Turn
82..84; 146..149; 214..217
Helix
50..52; 74..76; 79..81; 89..94; 106..108; 237..265
Beta Strand
26..31; 36..41; 45..47; 54..59; 62..68; 71..73; 85..87; 96..103; 110..131; 138..145; 150..161; 164..169; 177..183; 185..187; 191..200; 206..213; 218..225; 268..271
3D Structure
NMR spectroscopy (2); X-ray crystallography (63)
Domain & Motif Annotations
Domain (FT)
19..127; Ig-like V-type; 133..225; Ig-like C2-type
Protein Families
- Immunoglobulin superfamily
- BTN/MOG family
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Drug Targets
FDA approved drug targetsClinical trial target
Drugs
ANTI-PD-L1 MONOCLONAL ANTIBODY MDX-1105ZALIFRELIMABSOCAZOLIMABAVELUMABATEZOLIZUMABNULLENVAFOLIMABNIRAPARIBANTI-PD-L1/CD27 BISPECIFIC ANTIBODY CDX-527CARBOPLATINTORIPALIMAB-TPZIDABRAFENIBTISLELIZUMABCA-170RITUXIMABNIVOLUMABINCB086550BINTRAFUSP ALFACEMIPLIMAB-RWLCVACTOSERTIBNOFAZINLIMABENGINEERED TOXIN BODY TARGETING PD-L1 MT-6402RILVEGOSTOMIGPEMETREXED DISODIUMTRABECTEDINIPILIMUMABBETIFISOLIMABPEMBROLIZUMABDURVALUMABINCB-086550NAB-PACLITAXELDOXORUBICIN HYDROCHLORIDECADONILIMABSUGEMALIMABPEPINEMABERFONRILIMABPUCOTENLIMABBMS-936559CETRELIMABADO-TRASTUZUMAB EMTANSINEPEGILODECAKINPIMIVALIMABTRAMETINIB DIMETHYL SULFOXIDESERINE/THREONINE KINASE INHIBITOR CBP501SULFATINIBANTI-PD-L1 MONOCLONAL ANTIBODY FAZ053IMATINIBBALSTILIMABDOXORUBICIN LIPOSOMEIRINOTECAN HYDROCHLORIDEPD-L1/IDO PEPTIDE VACCINE IO102-103PACMILIMABANTI-LAG-3/PD-L1 BISPECIFIC ANTIBODY FS118CISPLATINMAGROLIMABONCOLYTIC TYPE 2 HERPES SIMPLEX VIRUS EXPRESSING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR OH2SHR-1316PIDILIZUMABJQ1ERIBULIN MESYLATEANLOTINIBARC FUSION PROTEIN SL-279252ANTI-PD-L1/CD137 BISPECIFIC ANTIBODY MCLA-145APL-501TREMELIMUMABAXITINIBBEVACIZUMAB-AWWBOXALIPLATINTIRAGOLUMABCAPECITABINESINTILIMABACASUNLIMABLODAPOLIMABGEMCITABINEPACLITAXELLMB-100ANTI-CD47/ANTI-PD-L1 BISPECIFIC ANTIBODY PF-07257876SASANLIMABRETIFANLIMABCOSIBELIMABDANBURSTOTUGFLUOROURACILRIVOCERANIBSPARTALIZUMABCAMRELIZUMAB
Interaction Protein
ENSG00000091317ENSG00000188389
Interaction Count
2
Interaction Dataset
intact_biogrid