Protein detail
CALL5
Calmodulin-like protein 5 (Calmodulin-like skin protein)
Entry name CALL5 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Calmodulin-like protein 5 (Calmodulin-like skin protein)
Protein Class
Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CLSP
Gene Description
Calmodulin like 5
Chromosome
10
Position
5498697-5499570
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04070 Phosphatidylinositol signaling system
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04625 C-type lectin receptor signaling pathway
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04744 Phototransduction
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04910 Insulin signaling pathway
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04924 Renin secretion
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05034 Alcoholism
- KEGG:hsa05133 Pertussis
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Flow cytometry | 1 | 35611462 |
Sequence, Structure & Domains
Sequences
Length
146
Mass
15,893
Sequence
MAGELTPEEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQDGRVNYEEFARMLAQE
3D Structural Models
Helix
80..87; 100..106; 107..109; 116..125; 138..143
Beta Strand
93..99; 128..135
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Domain (FT)
8..43; EF-hand 1; 44..74; EF-hand 2; 78..113; EF-hand 3; 114..146; EF-hand 4
Clinical Relevance
Antibody
Interaction Protein
ENSG00000158828
Interaction Count
1
Interaction Dataset
biogrid_bioplex