Protein detail
FLRT3
Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)
Entry name FLRT3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Disease related genes
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Transporters:Accessory Factors Involved in Transport
- Potential drug targets
Transmembrane
529..549; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Fibronectin leucine rich transmembrane protein 3
Chromosome
20
Position
14322985-14337614
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnon-classical monocyte
Function & Pathway7
Protein Function (4)
- Disease related genes
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Transporters:Accessory Factors Involved in Transport
- Potential drug targets
Cellular Component (14)
- GO:0005615 extracellular space
- GO:0005789 endoplasmic reticulum membrane
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005925 focal adhesion
- GO:0030054 cell junction
- GO:0031012 extracellular matrix
- GO:0032584 growth cone membrane
- GO:0043679 axon terminus
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Molecular Function (5)
Biological Process (3)
Reactome (6)
Canonical Pathways (2)
- M190 Pid tcr jnk pathway
- M34 Pid tcr pathway
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence54
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
Protein Complex Composition (8)
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FLRT3-LPHN3 complex | ADGRL3FLRT3 | Q9HAR2Q9NZU0 | 4:4 | CORUMPDB | CORUM:6529PDB:5cmn | 26235030 |
| FLRT3-LPHN3-UNC5D complex | ADGRL3FLRT3UNC5D | Q6UXZ4Q9HAR2Q9NZU0 | 0:0:0 | CORUM | CORUM:6528 | 26235030 |
| TENM2_FLRT3_complex | FLRT3TENM2 | Q9NT68Q9NZU0 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:TENM2_FLRT3_complex | |
| TENM3_FLRT3_complex | FLRT3TENM3 | Q9NZU0Q9P273 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:TENM3_FLRT3_complex | |
| TENM4_FLRT3_complex | FLRT3TENM4 | Q6N022Q9NZU0 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:TENM4_FLRT3_complex | |
| DHRS2FLRT3H2BC7PHB1PHB2 | P35232P62807Q13268Q99623Q9NZU0 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5236 | ||
| DHRS2FLRT3PHB1PHB2 | P35232Q13268Q99623Q9NZU0 | 1:1:1:1 | NetworkBlastCompleat | Compleat:HC6243 | ||
| FLRT3 | Q9NZU0 | 4 | PDB | PDB:5cmp |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31508500 |
Sequence, Structure & Domains11
Sequences
Length
649
Mass
73,004
Sequence
MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS
3D Structural Models
Turn
142..144; 147..152; 213..215; 218..223; 264..269; 288..293; 339..342
Helix
72..74; 77..81; 121..125; 192..195; 311..313; 314..321; 345..347
Beta Strand
35..38; 41..43; 62..64; 87..89; 108..110; 132..134; 158..160; 178..181; 203..205; 229..231; 251..253; 275..277; 299..301; 328..330; 333..338
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
389..401; Basic and acidic residues
Repeat
59..80; LRR 1; 84..104; LRR 2; 105..126; LRR 3; 129..150; LRR 4; 155..175; LRR 5; 176..197; LRR 6; 200..220; LRR 7; 226..247; LRR 8; 248..269; LRR 9; 272..293; LRR 10
Domain (FT)
29..58; LRRNT; 305..357; LRRCT; 409..504; Fibronectin type-III
Region
38..67; Interaction with ADGRL3; 387..407; Disordered; 622..649; Disordered
Clinical Relevance2
Disease Involvement (3)
Disease variantHypogonadotropic hypogonadismKallmann syndrome
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |