Protein detail

LMCD1

LIM and cysteine-rich domains protein 1 (Dyxin)

Entry name
LMCD1
UniProt ID
Q9NZU5
EVMP confidence score
0.53
Supporting publications (n)
4
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
LIM and cysteine-rich domains protein 1 (Dyxin)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000071282
Entrez Gene Symbol
LMCD1
Gene Description
LIM and cysteine rich domains 1
Chromosome
3
Position
8501807-8574668
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
LMCD1 fluorescence
Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome
R-hsa-5683826 surfactant metabolism
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence7

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ITPALMCD1PGAM1SERPINB1P18669P30740Q9BY32Q9NZU50:0:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry131414377
Sequence, Structure & Domains

Sequences

Length
365
Mass
40,833
Sequence
MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZU5-1; Sequence=Displayed; Name=2; IsoId=Q9NZU5-2; Sequence=VSP_053895
Alternative Sequence
1..73; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
208..220; Basic and acidic residues
Domain (CC)
The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6..
Domain (FT)
99..206; PET; 241..306; LIM zinc-binding 1; 307..365; LIM zinc-binding 2
Region
200..235; Disordered
Clinical Relevance
Antibody
HPA024059
Supporting Publications4
PMIDTitleRelated sentences
30915084Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.No related sentences available
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
40985879TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.No related sentences available