Protein detail
ADA22
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)
Protein symbol ADA22 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Transmembrane
737..757; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | No | Yes | No |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
906
Mass
100,433
Sequence
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Epsilon; IsoId=Q9P0K1-1; Sequence=Displayed; Name=2; Synonyms=Delta; IsoId=Q9P0K1-2; Sequence=VSP_005482, VSP_005484; Name=3; Synonyms=Alpha; IsoId=Q9P0K1-3; Sequence=VSP_005483; Name=4; Synonyms=Beta; IsoId=Q9P0K1-4; Sequence=VSP_005482, VSP_005483; Name=5; IsoId=Q9P0K1-5; Sequence=VSP_005482
Alternative Sequence
768..803; Missing (in isoform 2, isoform 4 and isoform 5); 859; E -> EYLNPWFKRDYNVAKWVEDVNKNTEGPYFR (in isoform 2); 860..906; Missing (in isoform 3 and isoform 4)
3D Structural Models
Turn
254..257; 351..353; 467..473; 536..539; 574..576
Helix
249..253; 259..280; 305..318; 363..378; 384..389; 416..427; 432..435; 463..466; 550..558; 567..573; 595..597; 671..674; 688..690
Beta Strand
235..237; 239..247; 281..292; 294..296; 325..333; 336..338; 341..343; 354..359; 390..392; 397..399; 449..451; 474..479; 486..488; 491..496; 502..504; 507..511; 540..543; 546..548; 578..581; 585..590; 600..602; 605..607; 613..617; 622..628; 631..637; 640..645; 646..648; 656..658; 661..666; 668..670; 692..695; 700..702; 706..708
3D Structure
Electron microscopy (2); X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
793..810; Low complexity; 811..829; Basic and acidic residues; 842..853; Basic residues; 862..877; Low complexity
Domain (FT)
239..438; Peptidase M12B; 444..531; Disintegrin; 675..712; EGF-like
Region
785..906; Disordered