Protein detail
CAC1I
Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3)
Entry name CAC1I | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 24 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3)
Protein Function (3)
- Voltage-gated ion channels:Voltage-Gated Calcium Channels
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Transmembrane
79..99; Helical; Name=S1 of repeat I; 121..141; Helical; Name=S2 of repeat I; 149..168; Helical; Name=S3 of repeat I; 174..191; Helical; Name=S4 of repeat I; 212..232; Helical; Name=S5 of repeat I; 378..398; Helical; Name=S6 of repeat I; 641..661; Helical; Name=S1 of repeat II; 677..697; Helical; Name=S2 of repeat II; 703..721; Helical; Name=S3 of repeat II; 730..753; Helical; Name=S4 of repeat II; 765..785; Helical; Name=S5 of repeat II; 842..862; Helical; Name=S6 of repeat II; 1167..1187; Helical; Name=S1 of repeat III; 1210..1230; Helical; Name=S2 of repeat III; 1245..1265; Helical; Name=S3 of repeat III; 1273..1294; Helical; Name=S4 of repeat III; 1305..1325; Helical; Name=S5 of repeat III; 1411..1431; Helical; Name=S6 of repeat III; 1486..1506; Helical; Name=S1 of repeat IV; 1523..1543; Helical; Name=S2 of repeat IV; 1557..1577; Helical; Name=S3 of repeat IV; 1584..1607; Helical; Name=S4 of repeat IV; 1622..1642; Helical; Name=S5 of repeat IV; 1710..1730; Helical; Name=S6 of repeat IV
Transmembrane Count
24
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificbone marrowCell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificependymal cellBlood Cell Specificbasophil
Function & Pathway7
Protein Function (3)
- Voltage-gated ion channels:Voltage-Gated Calcium Channels
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (7)
Reactome (5)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence21
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Sequence, Structure & Domains15
Sequences
Length
2,223
Mass
245,103
Sequence
MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Delta36b; IsoId=Q9P0X4-1; Sequence=Displayed; Name=2; IsoId=Q9P0X4-2; Sequence=VSP_000951; Name=3; Synonyms=Alpha1I-a; IsoId=Q9P0X4-3; Sequence=VSP_000950, VSP_000951; Name=4; IsoId=Q9P0X4-4; Sequence=VSP_000950
Alternative Sequence
488..523; HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE -> Q (in isoform 3 and isoform 4); 2010..2223; ATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASKRKR -> VPTPPRP (in isoform 2 and isoform 3)
3D Structural Models
Turn
101..103; 386..389; 726..728; 785..787; 832..834; 850..852; 1282..1288; 1468..1476; 1478..1485
Helix
67..77; 79..97; 110..137; 145..147; 149..169; 178..189; 193..205; 210..230; 234..236; 261..263; 319..322; 333..336; 343..354; 359..369; 372..374; 375..381; 390..412; 629..637; 642..659; 666..694; 696..701; 703..720; 732..743; 747..762; 768..784; 807..819; 823..831; 836..838; 839..849; 853..865; 1172..1187; 1199..1226; 1235..1237; 1239..1259; 1268..1280; 1290..1301; 1307..1327; 1346..1352; 1366..1377; 1382..1391; 1405..1407; 1408..1462; 1487..1504; 1513..1540; 1543..1548; 1552..1574; 1581..1589; 1590..1599; 1603..1613; 1616..1641; 1665..1675; 1680..1687; 1696..1699; 1702..1737
Beta Strand
139..144; 231..233; 238..240; 255..257; 272..274; 280..282; 326..328; 723..725; 793..796; 1228..1233; 1549..1551; 1647..1650; 1660..1664; 1692..1695
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
1..19; Low complexity; 912..936; Low complexity; 1770..1784; Gly residues; 2013..2028; Low complexity; 2029..2040; Polar residues; 2087..2096; Polar residues; 2098..2111; Basic and acidic residues; 2126..2136; Low complexity; 2137..2146; Pro residues; 2160..2176; Low complexity
Repeat
66..401; I; 626..865; II; 1157..1434; III; 1472..1733; IV
Domain (CC)
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Region
1..46; Disordered; 467..536; Disordered; 555..616; Disordered; 899..936; Disordered; 1758..1784; Disordered; 1868..1897; Disordered; 1937..1960; Disordered; 2013..2062; Disordered; 2076..2223; Disordered
Protein Families (2)
- Calcium channel alpha-1 subunit (TC 1.A.1.11) family
- CACNA1I subfamily
Sequence Similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily.
Clinical Relevance1
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No abstract available |