Protein detail

TM63C

Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C)

Entry name TM63C	UniProt ID Q9P1W3	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 11	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

38..62; Helical; Name=TM0; 127..159; Helical; Name=TM1; 183..207; Helical; Name=TM2; 404..433; Helical; Name=TM3; 449..478; Helical; Name=TM4; 483..519; Helical; Name=TM5; 543..575; Helical; Name=TM6; 596..614; Helical; Name=TM7; 618..642; Helical; Name=TM8; 650..678; Helical; Name=TM9; 684..704; Helical; Name=TM10

Transmembrane Count

Ensembl

ENSG00000165548

Entrez Gene Symbol

TMEM63C

Gene Synonym (4)

C14orf171CSC1DKFZp434P0111hsCSC1

Gene Description

Transmembrane protein 63C

Chromosome

Position

77116568-77259495

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue SpecificliverCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway5

Protein Function (5)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence21

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
tmem63_osmosensitive_cation	ion_channel	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NPPA PM20D1 TMEM63C	P01160 Q6GTS8 Q9P1W3	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingELISA	4	38225453 38731868 37686366 31759091

Sequence, Structure & Domains6

Sequences

Length

806

Mass

93,317

Sequence

MSASPDDLSTGGRLQNMTVDECFQSRNTVLQGQPFGGVPTVLCLNIALWVLVLVVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKTSPSETSLEMERRDKGFCSWFFNSITMKDEDLINKCGDDARIYIVFQYHLIIFVLIICIPSLGIILPINYTGSVLDWSSHFARTTIVNVSTESKLLWLHSLLSFFYFITNFMFMAHHCLGFAPRNSQKVTRTLMITYVPKDIEDPELIIKHFHEAYPGSVVTRVHFCYDVRNLIDLDDQRRHAMRGRLFYTAKAKKTGKVMIRIHPCARLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVPLKRLDLIFVTFQDSRMAKRVRKDYKYVQCGVQPQQSSVTTIVKSYYWRVTMAPHPKDIIWKHLSVRRFFWWARFIAINTFLFFLFFFLTTPAIIMNTIDMYNVTRPIEKLQNPIVTQFFPSVMLWGFTVILPLIVYFSAFLEAHWTRSSQNLVMVHKCYIFLVFMVVILPSMGLTSLDVFLRWLFDIYYLEQASIRFQCVFLPDNGAFFVNYVITAALLGTGMELLRLGSLFCYSTRLFFSRSEPERVNIRKNQAIDFQFGREYAWMMNVFSVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSFAPTKLNEQIHMAAVSQAIFAPLLGLFWMLFFSILRLGSLHAITIFSLSTLLIAMVIAFVGIFLGKLRMVADYEPEEEEIQTVFDMEPSSTSSTPTSLLYVATVLQEPELNLTPASSPARHTYGTMNNQPEEGEEESGLRGFARELDSAQFQEGLELEGQNQYH

Domain & Motif Annotations

Region

755..781; Disordered

Protein Families

CSC1 (TC 1.A.17) family

Sequence Similarities

Belongs to the CSC1 (TC 1.A.17) family.

Clinical Relevance2

Disease Involvement (3)

Disease variantHereditary spastic paraplegiaNeurodegeneration

Antibody

HPA030657

Supporting Publications2

PMID	Title	Abstract
34265469	Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.	Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes.
39408670	Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles.	No abstract available