Protein detail

TM63C

Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C)

Protein symbol TM63C	UniProt ID Q9P1W3	EVMP score 0.25
Frequency 2	Transmembrane count 11	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

38..62; Helical; Name=TM0; 127..159; Helical; Name=TM1; 183..207; Helical; Name=TM2; 404..433; Helical; Name=TM3; 449..478; Helical; Name=TM4; 483..519; Helical; Name=TM5; 543..575; Helical; Name=TM6; 596..614; Helical; Name=TM7; 618..642; Helical; Name=TM8; 650..678; Helical; Name=TM9; 684..704; Helical; Name=TM10

Transmembrane Count

Ensembl

ENSG00000165548

Entrez Gene Symbol

TMEM63C

Gene Synonym

C14orf171CSC1DKFZp434P0111hsCSC1

Gene Description

Transmembrane protein 63C

Chromosome

Position

77116568-77259495

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificliverCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
tmem63_osmosensitive_cation	ion_channel	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NPPA PM20D1 TMEM63C	P01160 Q6GTS8 Q9P1W3	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingELISA	4	38225453 38731868 37686366 31759091

Sequence, Structure & Domains

Sequences

Length

806

Mass

93,317

Sequence

MSASPDDLSTGGRLQNMTVDECFQSRNTVLQGQPFGGVPTVLCLNIALWVLVLVVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKTSPSETSLEMERRDKGFCSWFFNSITMKDEDLINKCGDDARIYIVFQYHLIIFVLIICIPSLGIILPINYTGSVLDWSSHFARTTIVNVSTESKLLWLHSLLSFFYFITNFMFMAHHCLGFAPRNSQKVTRTLMITYVPKDIEDPELIIKHFHEAYPGSVVTRVHFCYDVRNLIDLDDQRRHAMRGRLFYTAKAKKTGKVMIRIHPCARLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVPLKRLDLIFVTFQDSRMAKRVRKDYKYVQCGVQPQQSSVTTIVKSYYWRVTMAPHPKDIIWKHLSVRRFFWWARFIAINTFLFFLFFFLTTPAIIMNTIDMYNVTRPIEKLQNPIVTQFFPSVMLWGFTVILPLIVYFSAFLEAHWTRSSQNLVMVHKCYIFLVFMVVILPSMGLTSLDVFLRWLFDIYYLEQASIRFQCVFLPDNGAFFVNYVITAALLGTGMELLRLGSLFCYSTRLFFSRSEPERVNIRKNQAIDFQFGREYAWMMNVFSVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSFAPTKLNEQIHMAAVSQAIFAPLLGLFWMLFFSILRLGSLHAITIFSLSTLLIAMVIAFVGIFLGKLRMVADYEPEEEEIQTVFDMEPSSTSSTPTSLLYVATVLQEPELNLTPASSPARHTYGTMNNQPEEGEEESGLRGFARELDSAQFQEGLELEGQNQYH

3D Structural Models

Domain & Motif Annotations

Region

755..781; Disordered

Protein Families

CSC1 (TC 1.A.17) family

Sequence Similarities

Belongs to the CSC1 (TC 1.A.17) family.

Clinical Relevance

Disease Involvement

Disease variantHereditary spastic paraplegiaNeurodegeneration

Antibody

HPA030657