Protein detail

NHSL3

NHS-like protein 3

Entry name NHSL3	UniProt ID Q9P206	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

NHS-like protein 3

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000162522

Entrez Gene Symbol

NHSL3

Gene Description

KIAA1522

Chromosome

Position

32741830-32774970

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificblood vesselCell SpecificLate spermatidsSingle-Nuclei Brain Specificvascular associated smooth muscle cellBlood Cell Specificneutrophil

Function & Pathway4

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	2	38343172 39025337

Sequence, Structure & Domains7

Sequences

Length

1,035

Mass

107,095

Sequence

MVVFVGRRLPALLGLFKKKGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQKELA

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9P206-1; Sequence=Displayed; Name=2; IsoId=Q9P206-2; Sequence=VSP_040217; Name=3; IsoId=Q9P206-3; Sequence=VSP_041634; Name=4; IsoId=Q9P206-4; Sequence=VSP_043215

Alternative Sequence

1..19; MVVFVGRRLPALLGLFKKK -> MAARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAPRAKKAEDKAKRAKGKGR (in isoform 2); 1..19; MVVFVGRRLPALLGLFKKK -> MGNSHHKRKAPSGPRVRSFWRFGRSAKRPA (in isoform 3); 137..1028; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

76..90; Basic and acidic residues; 338..365; Low complexity; 366..388; Polar residues; 411..429; Polar residues; 431..449; Basic residues; 517..532; Low complexity; 543..552; Pro residues; 562..589; Low complexity; 602..624; Pro residues; 625..645; Low complexity; 652..662; Low complexity; 669..685; Pro residues; 709..718; Pro residues; 737..765; Low complexity; 771..784; Pro residues; 838..848; Low complexity; 894..906; Pro residues; 961..980; Pro residues; 999..1008; Basic and acidic residues

Region

23..44; Disordered; 76..105; Disordered; 133..162; Disordered; 332..869; Disordered; 885..1035; Disordered

Clinical Relevance4

Antibody (3)

HPA032050 HPA032051 HPA064839

Interaction Protein (5)

ENSG00000061676ENSG00000112290ENSG00000158092ENSG00000158195ENSG00000175866

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid

Supporting Publications3

PMID	Title	Abstract
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available