Protein detail

RHG23

Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)

Entry name RHG23	UniProt ID Q9P227	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000275832

Entrez Gene Symbol

ARHGAP23

Gene Synonym

KIAA1501

Gene Description

Rho GTPase activating protein 23

Chromosome

Position

38419280-38512385

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0005096 GTPase activator activity

Biological Process (3)

Reactome (4)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence9

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGAP23	AURKB	Q96GD4	S	127	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RHG23	Q9P227	RAC1	P63000	Yes	No	Yes	SIGNOR	SIGNOR:32203420
RHG23	Q9P227	RHOA	P61586	Yes	No	Yes	SIGNOR	SIGNOR:32203420

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP23 HNRNPA1 KPNA7 NOP14 RBM39 RPS11 RPS13 RPS17 RPS19 RPS3 RPS3A RPS8 RPS9 SUMO1 UBC	A9QM74 P08708 P09651 P0CG48 P23396 P39019 P46781 P61247 P62241 P62277 P62280 P63165 P78316 Q14498 Q9P227	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8395
	ARHGAP23 HNRNPA1 PRMT1 PRMT8 RPAP1 SRP72 UBC	O76094 P09651 P0CG48 Q99873 Q9BWH6 Q9NR22 Q9P227	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7791

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingR SequencingFlow cytometryMORPH	4	37862381 38937789 26538482 38731868

Sequence, Structure & Domains8

Sequences

Length

1,491

Mass

162,192

Sequence

MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P227-1; Sequence=Displayed; Name=2; IsoId=Q9P227-2; Sequence=VSP_023708, VSP_023709

Alternative Sequence

1139..1144; DSTTCS -> ADLLEI (in isoform 2); 1145..1491; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

482..491; Basic and acidic residues; 1138..1148; Polar residues; 1245..1257; Polar residues; 1345..1366; Low complexity

Domain (FT)

71..155; PDZ; 688..808; PH; 905..1097; Rho-GAP

Region

15..34; Disordered; 204..280; Disordered; 385..407; Disordered; 449..530; Disordered; 831..851; Disordered; 1126..1155; Disordered; 1175..1367; Disordered; 1420..1491; Disordered

Clinical Relevance1

Antibody (2)

HPA019818 HPA047291

Supporting Publications1

PMID	Title	Abstract
39569406	Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.	No abstract available