Protein detail

AT10D

Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)

Entry name AT10D	UniProt ID Q9P241	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 10	Protein classification EnzymesPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)

Protein Class (3)

EnzymesPredicted membrane proteinsTransporters

Protein Function (3)

Enzymes
ENZYME proteins
Transporters:Primary Active Transporters

Transmembrane

98..118; Helical; 122..142; Helical; 322..342; Helical; 366..386; Helical; 1114..1134; Helical; 1146..1166; Helical; 1196..1216; Helical; 1225..1245; Helical; 1253..1273; Helical; 1293..1313; Helical

Transmembrane Count

Ensembl

ENSG00000145246

Entrez Gene Symbol

ATP10D

Gene Synonym (2)

ATPVDKIAA1487

Gene Description

ATPase phospholipid transporting 10D (putative)

Chromosome

Position

47485275-47593486

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificNeutrophil progenitors

Function & Pathway7

Protein Function (3)

Enzymes
ENZYME proteins
Transporters:Primary Active Transporters

Cellular Component (6)

Molecular Function (6)

Biological Process (3)

Reactome (3)

Canonical Pathways

M272 Pid cd8 tcr downstream pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence16

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Flow cytometry	2	35611462 27894104

Sequence, Structure & Domains9

Sequences

Length

1,426

Mass

160,274

Sequence

MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPSAVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P241-1; Sequence=Displayed; Name=2; IsoId=Q9P241-2; Sequence=VSP_006954

Alternative Sequence

553..747; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

512..524; Polar residues

Region

506..531; Disordered

Protein Families (2)

Cation transport ATPase (P-type) (TC 3.A.3) family
Type IV subfamily

Sequence Similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

Clinical Relevance1

Antibody

HPA050808

Supporting Publications1

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available