Protein detail

UNC79

Protein unc-79 homolog

Entry name UNC79	UniProt ID Q9P2D8	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 2	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Protein unc-79 homolog

Protein Function

Transporters:Transporter channels and pores

Transmembrane

2223..2243; Helical; 2466..2486; Helical

Transmembrane Count

Ensembl

ENSG00000133958

Entrez Gene Symbol

UNC79

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function

Transporters:Transporter channels and pores

Cellular Component

GO:0005886 plasma membrane

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M5883 Naba secreted factors
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence13

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UNC80	Q8N2C7	UNC79	Q9P2D8	Yes	Yes	No	HINTSIGNOR	HINT:35387979 SIGNOR:22196327 HINT:34929720

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	35611462 28986585 33709510 38321535 32089743

Sequence, Structure & Domains13

Sequences

Length

2,635

Mass

295,326

Sequence

MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDILSTLPYTMISTLATFPPFLHKDIIEYLSTSFLPMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERIAGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGAAAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNADFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVINQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSSVQEQALLWLHVLSELDIMVPLQLLISMFSDGVNSVKELANQRKSRVSELAGNLASRRVSVASDPGRRVQHNMLSPFHSPFQSPFRSPLRSPFRSPFKNFGHPGGRTIDFDCEDDEMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHTCQKDEKAIECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSSRPEFIIGPEGEEEENPASKHGENPGNCTEPVEHAAVKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYIARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPVESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMAKDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDISKILLHLIHITVNTLNAQYHSCKPHATAGPLYSDNSNISRYSEKEKGEIELAEYRETGALQDSLLHCVREESIPKKKLRSFKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIEKPPTQAAYIAQRPNDPGRSRQNSATRPDNSEIPENPAMEGFPDARRPVIPEVRLNCMETFEVKVDSPVKPAPKEDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEEETMNQGDDGPSGKNAASSPSVPSHPSVLSLSTAPLVQVSVEDCSKDFSSKDSGNNQSAGNTDSALITLEDPMDAEGSSKPEELPEFSCGSPLTLKQKRDLLQKSFALPEMSLDDHPDPGTEGEKPGELMPSSGAKTVLLKVPEDAENPTESEKPDTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPDPSTKGLSTLEMPRESSSAPTLDAGVPETSSHSSISTQYRQMKRGSLGVLTMSQLMKRQLEHQSSAPHNISNWDTEQIQPGKRQCNVPTCLNPDLEGQPLRMRGATKSSLLSAPSIVSMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSTIKDGTFLRTLASSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECVRQYINEVLDFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMDISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHVADHLIVILIGFPEQSKTSVLHMCSLFHAFIFAQLWTVYCEQSAVATNLQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNIKHLSAGLQLRLQAIQNHVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P2D8-1; Sequence=Displayed; Name=2; IsoId=Q9P2D8-2; Sequence=VSP_030583; Name=3; IsoId=Q9P2D8-3; Sequence=VSP_030584

Alternative Sequence

1..177; Missing (in isoform 2); 1252; R -> PMRLTRHEQSAPALGGTPEQTPG (in isoform 3)

3D Structural Models

Turn

638..641; 984..986; 1221..1223; 1320..1322

Helix

176..179; 180..183; 187..199; 201..205; 222..233; 237..250; 254..264; 267..269; 270..280; 282..284; 435..437; 440..455; 498..510; 520..537; 554..567; 569..576; 596..610; 611..613; 619..634; 644..651; 663..666; 668..671; 672..674; 679..694; 701..715; 797..815; 826..840; 860..878; 951..963; 969..983; 988..995; 997..1006; 1008..1014; 1021..1035; 1040..1052; 1057..1072; 1076..1079; 1083..1099; 1105..1115; 1120..1136; 1138..1140; 1141..1154; 1163..1180; 1209..1219; 1228..1231; 1273..1289; 1299..1315; 1329..1334; 1336..1351; 1353..1371; 1376..1379; 1387..1389; 1392..1408; 1414..1432; 2020..2036; 2038..2041; 2042..2044; 2045..2057; 2074..2089; 2090..2092; 2094..2099; 2108..2115; 2124..2137; 2145..2158; 2170..2181; 2182..2186; 2195..2205; 2210..2214; 2217..2230; 2235..2248; 2252..2270; 2278..2292; 2319..2324; 2325..2333; 2337..2342; 2357..2377; 2383..2387; 2389..2392; 2407..2428; 2441..2443; 2444..2457; 2471..2488; 2504..2526; 2531..2547; 2551..2565; 2576..2584; 2605..2624

Beta Strand

652..655; 675..677; 1325..1327; 1380..1382; 2120..2122; 2138..2140

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

1666..1678; Low complexity; 1699..1713; Polar residues; 1761..1775; Basic and acidic residues; 1897..1909; Polar residues; 1929..1947; Polar residues

Region

907..929; Disordered; 1538..1575; Disordered; 1607..1678; Disordered; 1693..1832; Disordered; 1863..1909; Disordered; 1929..1950; Disordered

Protein Families

Unc-79 family

Sequence Similarities

Belongs to the unc-79 family.

Supporting Publications1

PMID	Title	Abstract
34265469	Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.	Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes.