Protein detail

UNC79

Protein unc-79 homolog

Entry name UNC79	UniProt ID Q9P2D8	EVMP score 0.50
Frequency 1	Transmembrane count 2	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein unc-79 homolog

Protein Function

Transporters:Transporter channels and pores

Transmembrane

2223..2243; Helical; 2466..2486; Helical

Transmembrane Count

Ensembl

ENSG00000133958

Entrez Gene Symbol

UNC79

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

GO:0005886 plasma membrane

Biological Process

Reactome

Canonical Pathways

M5883 Naba secreted factors
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UNC80	Q8N2C7	UNC79	Q9P2D8	Yes	Yes	No	HINTSIGNOR	HINT:35387979 SIGNOR:22196327 HINT:34929720

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	35611462 28986585 33709510 38321535 32089743

Sequence, Structure & Domains

Sequences

Length

2,635

Mass

295,326

Sequence

MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDILSTLPYTMISTLATFPPFLHKDIIEYLSTSFLPMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERIAGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGAAAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNADFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVINQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSSVQEQALLWLHVLSELDIMVPLQLLISMFSDGVNSVKELANQRKSRVSELAGNLASRRVSVASDPGRRVQHNMLSPFHSPFQSPFRSPLRSPFRSPFKNFGHPGGRTIDFDCEDDEMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHTCQKDEKAIECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSSRPEFIIGPEGEEEENPASKHGENPGNCTEPVEHAAVKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYIARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPVESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMAKDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDISKILLHLIHITVNTLNAQYHSCKPHATAGPLYSDNSNISRYSEKEKGEIELAEYRETGALQDSLLHCVREESIPKKKLRSFKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIEKPPTQAAYIAQRPNDPGRSRQNSATRPDNSEIPENPAMEGFPDARRPVIPEVRLNCMETFEVKVDSPVKPAPKEDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEEETMNQGDDGPSGKNAASSPSVPSHPSVLSLSTAPLVQVSVEDCSKDFSSKDSGNNQSAGNTDSALITLEDPMDAEGSSKPEELPEFSCGSPLTLKQKRDLLQKSFALPEMSLDDHPDPGTEGEKPGELMPSSGAKTVLLKVPEDAENPTESEKPDTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPDPSTKGLSTLEMPRESSSAPTLDAGVPETSSHSSISTQYRQMKRGSLGVLTMSQLMKRQLEHQSSAPHNISNWDTEQIQPGKRQCNVPTCLNPDLEGQPLRMRGATKSSLLSAPSIVSMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSTIKDGTFLRTLASSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECVRQYINEVLDFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMDISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHVADHLIVILIGFPEQSKTSVLHMCSLFHAFIFAQLWTVYCEQSAVATNLQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNIKHLSAGLQLRLQAIQNHVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P2D8-1; Sequence=Displayed; Name=2; IsoId=Q9P2D8-2; Sequence=VSP_030583; Name=3; IsoId=Q9P2D8-3; Sequence=VSP_030584

Alternative Sequence

1..177; Missing (in isoform 2); 1252; R -> PMRLTRHEQSAPALGGTPEQTPG (in isoform 3)

3D Structural Models

Turn

638..641; 984..986; 1221..1223; 1320..1322

Helix

176..179; 180..183; 187..199; 201..205; 222..233; 237..250; 254..264; 267..269; 270..280; 282..284; 435..437; 440..455; 498..510; 520..537; 554..567; 569..576; 596..610; 611..613; 619..634; 644..651; 663..666; 668..671; 672..674; 679..694; 701..715; 797..815; 826..840; 860..878; 951..963; 969..983; 988..995; 997..1006; 1008..1014; 1021..1035; 1040..1052; 1057..1072; 1076..1079; 1083..1099; 1105..1115; 1120..1136; 1138..1140; 1141..1154; 1163..1180; 1209..1219; 1228..1231; 1273..1289; 1299..1315; 1329..1334; 1336..1351; 1353..1371; 1376..1379; 1387..1389; 1392..1408; 1414..1432; 2020..2036; 2038..2041; 2042..2044; 2045..2057; 2074..2089; 2090..2092; 2094..2099; 2108..2115; 2124..2137; 2145..2158; 2170..2181; 2182..2186; 2195..2205; 2210..2214; 2217..2230; 2235..2248; 2252..2270; 2278..2292; 2319..2324; 2325..2333; 2337..2342; 2357..2377; 2383..2387; 2389..2392; 2407..2428; 2441..2443; 2444..2457; 2471..2488; 2504..2526; 2531..2547; 2551..2565; 2576..2584; 2605..2624

Beta Strand

652..655; 675..677; 1325..1327; 1380..1382; 2120..2122; 2138..2140

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

1666..1678; Low complexity; 1699..1713; Polar residues; 1761..1775; Basic and acidic residues; 1897..1909; Polar residues; 1929..1947; Polar residues

Region

907..929; Disordered; 1538..1575; Disordered; 1607..1678; Disordered; 1693..1832; Disordered; 1863..1909; Disordered; 1929..1950; Disordered

Protein Families

Unc-79 family

Sequence Similarities

Belongs to the unc-79 family.

Clinical Relevance