Protein detail

STX18

Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Protein symbol STX18	UniProt ID Q9P2W9	EVMP score 0.50
Frequency 5	Transmembrane count 1	Protein classification Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Protein Class

Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

310..330; Helical; Anchor for type IV membrane protein

Transmembrane Count

Ensembl

ENSG00000168818

Entrez Gene Symbol

STX18

Gene Synonym

Ufe1

Gene Description

Syntaxin 18

Chromosome

Position

4415742-4542346

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificurinary bladderCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lip

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BNIP1 SEC22B STX18	O75396 Q12981 Q9P2W9	0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	2	30608700 40098346

Sequence, Structure & Domains

Sequences

Length

335

Mass

38,674

Sequence

MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS

3D Structural Models

Domain & Motif Annotations

Compositional Bias

168..182; Basic and acidic residues; 192..208; Basic and acidic residues

Domain (FT)

243..305; t-SNARE coiled-coil homology

Region

168..226; Disordered

Protein Families

Syntaxin family

Sequence Similarities

Belongs to the syntaxin family.

Clinical Relevance

Antibody

HPA003019

Interaction Protein

ENSG00000053501ENSG00000086827ENSG00000092108ENSG00000099940ENSG00000105402ENSG00000113734ENSG00000135249ENSG00000135823ENSG00000144867ENSG00000151779ENSG00000184178ENSG00000265808

Interaction Count

Interaction Dataset

intact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexbiogrid_opencell