Protein detail

STX18

Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Entry name
STX18
UniProt ID
Q9P2W9
EVMP confidence score
0.28
Supporting publications (n)
4
Transmembrane count
1
Protein classification
Essential proteinsPredicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)
Protein Class (3)
Essential proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
310..330; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
ENSG00000168818
Entrez Gene Symbol
STX18
Gene Synonym
Ufe1
Gene Description
Syntaxin 18
Chromosome
4
Position
4415742-4542346
Supporting publications (n)
4
EVMP confidence score
0.28
Fluorescence & Localization
STX18 fluorescence
Tissue Specificurinary bladderCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lip
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
KEGG (2)
Reactome (5)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27

Ligand-Receptor Signaling (15)

15 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembrane_predictedtransmembraneOmniPath
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
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Protein Complex Composition (11)

11 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
BNIP1SEC22BSTX18O75396Q12981Q9P2W90:0:0hu.MAP2
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryWestern blotting23060870040098346
Sequence, Structure & Domains

Sequences

Length
335
Mass
38,674
Sequence
MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS

Domain & Motif Annotations

Compositional Bias
168..182; Basic and acidic residues; 192..208; Basic and acidic residues
Domain (FT)
243..305; t-SNARE coiled-coil homology
Region
168..226; Disordered
Protein Families
Syntaxin family
Sequence Similarities
Belongs to the syntaxin family.
Clinical Relevance
Antibody
HPA003019
Interaction Protein (12)
ENSG00000053501ENSG00000086827ENSG00000092108ENSG00000099940ENSG00000105402ENSG00000113734ENSG00000135249ENSG00000135823ENSG00000144867ENSG00000151779ENSG00000184178ENSG00000265808
Interaction Count
12
Interaction Dataset (4)
intact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexbiogrid_opencell
Supporting Publications4
PMIDTitleRelated sentences
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available
41307968Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.No related sentences available