Protein detail
STX18
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)
Entry name STX18 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Essential proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)
Protein Class (3)
Essential proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
310..330; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
Ufe1
Gene Description
Syntaxin 18
Chromosome
4
Position
4415742-4542346
Supporting publications (n)
5
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificurinary bladderCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lip
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Reactome (5)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Protein Complex Composition (11)
11 records.
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Sequence, Structure & Domains8
Sequences
Length
335
Mass
38,674
Sequence
MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS
Domain & Motif Annotations
Compositional Bias
168..182; Basic and acidic residues; 192..208; Basic and acidic residues
Domain (FT)
243..305; t-SNARE coiled-coil homology
Region
168..226; Disordered
Protein Families
Syntaxin family
Sequence Similarities
Belongs to the syntaxin family.
Clinical Relevance4
Antibody
Interaction Protein (12)
ENSG00000053501ENSG00000086827ENSG00000092108ENSG00000099940ENSG00000105402ENSG00000113734ENSG00000135249ENSG00000135823ENSG00000144867ENSG00000151779ENSG00000184178ENSG00000265808
Interaction Count
12
Interaction Dataset (4)
intact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexbiogrid_opencell
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |