Protein detail

STX18

Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Entry name STX18	UniProt ID Q9P2W9	EVMP confidence score 0.28
Supporting publications (n) 4	Transmembrane count 1	Protein classification Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Protein Class (3)

Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

310..330; Helical; Anchor for type IV membrane protein

Transmembrane Count

Ensembl

ENSG00000168818

Entrez Gene Symbol

STX18

Gene Synonym

Ufe1

Gene Description

Syntaxin 18

Chromosome

Position

4415742-4542346

Supporting publications (n)

EVMP confidence score

0.28

Fluorescence & Localization

Tissue Specificurinary bladderCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lip

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence27

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database
transmembrane	transmembrane	OmniPath
transmembrane	transmembrane_predicted	Phobius
transmembrane_phobius	transmembrane_predicted	Almen2009
transmembrane_sosui	transmembrane_predicted	Almen2009
transmembrane_tmhmm	transmembrane_predicted	Almen2009

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Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Dsl1p complex	BNIP1 NELFCD RINT1 STX18 USE1	Q12981 Q6NUQ1 Q8IXH7 Q9NZ43 Q9P2W9	1:1:1:1:1	Compleat	Compleat:HC130	15958492
HT_SC_Cluster61	BNIP1 NELFCD RINT1 SEC22A SEC22B SEC22C STX18 USE1 YKT6	O15498 O75396 Q12981 Q6NUQ1 Q8IXH7 Q96IW7 Q9BRL7 Q9NZ43 Q9P2W9	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2799
	BNIP1 C19orf25 KNTC1 NBAS RINT1 SCFD2 STX18 USE1 ZW10 ZWILCH	A2RRP1 O43264 P50748 Q12981 Q6NUQ1 Q8WU76 Q9H900 Q9NZ43 Q9P2W9 Q9UFG5	0:0:0:0:0:0:0:0:0:0	hu.MAP2
	BNIP1 C19orf25 NBAS RINT1 SCFD1 SCFD2 STX18 USE1 ZW10 ZWILCH	A2RRP1 O43264 Q12981 Q6NUQ1 Q8WU76 Q8WVM8 Q9H900 Q9NZ43 Q9P2W9 Q9UFG5	0:0:0:0:0:0:0:0:0:0	hu.MAP
	BNIP1 NBAS SCFD1 SCFD2 STX18 USE1	A2RRP1 Q12981 Q8WU76 Q8WVM8 Q9NZ43 Q9P2W9	0:0:0:0:0:0	hu.MAP
	BNIP1 NBAS SCFD1 STX18	A2RRP1 Q12981 Q8WVM8 Q9P2W9	0:0:0:0	hu.MAP
	BET1L BLTP2 BNIP1 GOSR1 GOSR2 KIF3C NAPA RINT1 SCFD1 SEC22B STX18 STX5 UBC USE1 YKT6	O14653 O14782 O15498 O75396 O95249 P0CG48 P54920 Q12981 Q13190 Q14667 Q6NUQ1 Q8WVM8 Q9NYM9 Q9NZ43 Q9P2W9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8816
	BET1L BNIP1 GOSR1 GOSR2 NAPA NUDT3 RINT1 SCFD1 SEC22B STX18 STX5 UBC USE1 XPNPEP1 YKT6	O14653 O15498 O75396 O95249 O95989 P0CG48 P54920 Q12981 Q13190 Q6NUQ1 Q8WVM8 Q9NQW7 Q9NYM9 Q9NZ43 Q9P2W9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7159
	BET1L BNIP1 GOSR1 GOSR2 NAPA NSF RINT1 SCFD1 SEC22B STX12 STX18 STX5 UBC USE1 YKT6	O14653 O15498 O75396 O95249 P0CG48 P46459 P54920 Q12981 Q13190 Q6NUQ1 Q86Y82 Q8WVM8 Q9NYM9 Q9NZ43 Q9P2W9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4537
	BET1 BNIP1 SCFD1 SEC22B STX18	O15155 O75396 Q12981 Q8WVM8 Q9P2W9	0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	2	30608700 40098346

Sequence, Structure & Domains

Sequences

Length

335

Mass

38,674

Sequence

MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHKEIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRESTSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS

Domain & Motif Annotations

Compositional Bias

168..182; Basic and acidic residues; 192..208; Basic and acidic residues

Domain (FT)

243..305; t-SNARE coiled-coil homology

Region

168..226; Disordered

Protein Families

Syntaxin family

Sequence Similarities

Belongs to the syntaxin family.

Clinical Relevance

Antibody

HPA003019

Interaction Protein (12)

ENSG00000053501ENSG00000086827ENSG00000092108ENSG00000099940ENSG00000105402ENSG00000113734ENSG00000135249ENSG00000135823ENSG00000144867ENSG00000151779ENSG00000184178ENSG00000265808

Interaction Count

Interaction Dataset (4)

intact_biogrid_opencell_bioplexbiogrid_opencell_bioplexbiogrid_bioplexbiogrid_opencell

Supporting Publications4

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No related sentences available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No related sentences available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No related sentences available