Protein detail
ATX10
Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)
Entry name ATX10 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)
Protein Class (4)
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
ATX10E46LFLJ37990SCA10
Gene Description
Ataxin 10
Chromosome
22
Position
45671798-45845307
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component (11)
- GO:0005615 extracellular space
- GO:0005737 cytoplasm
- GO:0005814 centriole
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0030496 midbody
- GO:0036064 ciliary basal body
- GO:0043025 neuronal cell body
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Molecular Function
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence20
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATXN10 | PLK1 | P53350 | T | 82 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21857149ProtMapper:25666058ProtMapper:21857149 |
| ATXN10 | PLK1 | P53350 | S | 77 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21857149ProtMapper:25666058ProtMapper:21857149 |
| ATXN10 | AURKB | Q96GD4 | S | 12 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ATXN10 | AURKB | Q96GD4 | S | 77 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:25666058 |
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | |||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | Cellinker |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PLK1 | P53350 | ATX10 | Q9UBB4 | Yes | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21857149SIGNOR:21857149ProtMapper:25666058ProtMapper:21857149 | |
| AURKB | Q96GD4 | ATX10 | Q9UBB4 | Yes | iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:25666058PhosphoSite:25666058 |
Protein Complex Composition (2)
Sequence, Structure & Domains
Sequences
Length
475
Mass
53,489
Sequence
MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBB4-1; Sequence=Displayed; Name=2; IsoId=Q9UBB4-2; Sequence=VSP_042526
Alternative Sequence
40..103; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
Ataxin-10 family
Sequence Similarities
Belongs to the ataxin-10 family.
Clinical Relevance
Disease Involvement (3)
CiliopathyNeurodegenerationSpinocerebellar ataxia
Related Diseases
Antibody
Interaction Protein (3)
ENSG00000058272ENSG00000136997ENSG00000164163
Interaction Count
3
Interaction Dataset (3)
intact_biogrid_opencellintact_biogridbiogrid_opencell
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |