Protein detail

ATX10

Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)

Entry name ATX10	UniProt ID Q9UBB4	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)

Protein Class (4)

Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000130638

Entrez Gene Symbol

ATXN10

Gene Synonym (4)

ATX10E46LFLJ37990SCA10

Gene Description

Ataxin 10

Chromosome

Position

45671798-45845307

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway6

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Cellular Component (11)

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Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG

hsa05017 Spinocerebellar ataxia

Mediation Categories

Other mediation

Relations & Evidence20

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ATXN10	PLK1	P53350	T	82	phosphorylation	Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21857149 ProtMapper:25666058 ProtMapper:21857149
ATXN10	PLK1	P53350	S	77	phosphorylation	Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21857149 ProtMapper:25666058 ProtMapper:21857149
ATXN10	AURKB	Q96GD4	S	12	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
ATXN10	AURKB	Q96GD4	S	77	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:25666058

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PLK1	P53350	ATX10	Q9UBB4	Yes	No	Yes	Sparser_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21857149 SIGNOR:21857149 ProtMapper:25666058 ProtMapper:21857149
AURKB	Q96GD4	ATX10	Q9UBB4	Yes	No	No	iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:25666058 PhosphoSite:25666058

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATXN10 MTG1 PUSL1 TRIP13	Q15645 Q8N0Z8 Q9BT17 Q9UBB4	0:0:0:0	hu.MAP2
	ATXN10 TRIP13	Q15645 Q9UBB4	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Flow cytometry	2	35611462 33709510

Sequence, Structure & Domains7

Sequences

Length

475

Mass

53,489

Sequence

MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBB4-1; Sequence=Displayed; Name=2; IsoId=Q9UBB4-2; Sequence=VSP_042526

Alternative Sequence

40..103; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families

Ataxin-10 family

Sequence Similarities

Belongs to the ataxin-10 family.

Clinical Relevance5

Disease Involvement (3)

CiliopathyNeurodegenerationSpinocerebellar ataxia

Antibody

HPA049531

Interaction Protein (3)

ENSG00000058272ENSG00000136997ENSG00000164163

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellintact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available