Protein detail
TR10D
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)
Entry name TR10D | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Transmembrane
212..232; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificCardiomyocytesSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificNK-cell
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (2)
Reactome (8)
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-73887 death receptor signaling
- R-hsa-109582 hemostasis
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-5633008 tp53 regulates transcription of cell death genes
- R-hsa-6803211 tp53 regulates transcription of death receptors and ligands
- R-hsa-75158 trail signaling
- R-hsa-3700989 transcriptional regulation by tp53
Mediation Categories
Immune mediation
Relations & Evidence51
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TR10D | Q9UBN6 | TNF10 | P50591 | Yes | No | Yes | HPMRSIGNORHPRDHINTDIPLit-BM-17 | DIP:9382840HPMR:9242610HINT:20103630HINT:9430226HINT:9382840SIGNOR:9382840Lit-BM-17:9430226HPRD:9430226Lit-BM-17:20103630Lit-BM-17:9382840 |
Sequence, Structure & Domains7
Sequences
Length
386
Mass
41,849
Sequence
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL
Domain & Motif Annotations
Compositional Bias
64..75; Polar residues
Repeat
58..97; TNFR-Cys 1; 98..139; TNFR-Cys 2; 140..180; TNFR-Cys 3
Domain (FT)
340..366; Death; truncated
Region
1..25; Disordered; 62..90; Disordered
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |