Protein detail
TR10D
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)
Protein symbol TR10D | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Transmembrane
212..232; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCardiomyocytesSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificNK-cell
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-73887 death receptor signaling
- R-hsa-109582 hemostasis
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-5633008 tp53 regulates transcription of cell death genes
- R-hsa-6803211 tp53 regulates transcription of death receptors and ligands
- R-hsa-75158 trail signaling
- R-hsa-3700989 transcriptional regulation by tp53
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| tumor_necrosis_factor | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TR10D | Q9UBN6 | TNF10 | P50591 | Yes | No | Yes | HPMRSIGNORHPRDHINTDIPLit-BM-17 | DIP:9382840HPMR:9242610HINT:20103630HINT:9430226HINT:9382840SIGNOR:9382840Lit-BM-17:9430226HPRD:9430226Lit-BM-17:20103630Lit-BM-17:9382840 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
386
Mass
41,849
Sequence
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL
3D Structural Models
Domain & Motif Annotations
Compositional Bias
64..75; Polar residues
Repeat
58..97; TNFR-Cys 1; 98..139; TNFR-Cys 2; 140..180; TNFR-Cys 3
Domain (FT)
340..366; Death; truncated
Region
1..25; Disordered; 62..90; Disordered