Protein detail
GABR1
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)
Protein symbol GABR1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPlasma proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPlasma proteinsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Family 3 (C) receptors
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
592..612; Helical; Name=1; 632..652; Helical; Name=2; 668..688; Helical; Name=3; 711..731; Helical; Name=4; 769..789; Helical; Name=5; 805..825; Helical; Name=6; 834..854; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPRC3AhGB1a
Gene Description
Gamma-aminobutyric acid type B receptor subunit 1
Chromosome
6
Position
29555629-29633976
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificProstatic glandular cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- G-protein coupled receptors:Family 3 (C) receptors
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
- GO:0005615 extracellular space
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0030673 axolemma
- GO:0031966 mitochondrial membrane
- GO:0038039 G protein-coupled receptor heterodimeric complex
- GO:0042734 presynaptic membrane
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0043198 dendritic shaft
- GO:0045211 postsynaptic membrane
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
- GO:1902712 G protein-coupled GABA receptor complex
Molecular Function
- GO:0004965 G protein-coupled GABA receptor activity
- GO:0005515 protein binding
- GO:0046982 protein heterodimerization activity
- GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
- GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
- GO:1990430 extracellular matrix protein binding
Biological Process
KEGG
Reactome
- R-hsa-420499 class c 3 metabotropic glutamate pheromone receptors
- R-hsa-977444 gaba b receptor activation
- R-hsa-977443 gaba receptor activation
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-1296065 inwardly rectifying k channels
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-1296071 potassium channels
- R-hsa-372790 signaling by gpcr
- R-hsa-112315 transmission across chemical synapses
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GABBR1 | CAMK2A | Q9UQM7 | S | 868 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:20643921SIGNOR:20643921 |
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | Yes | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| glutamate | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | Yes | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | Yes | Yes | No |
| 7tm_c | receptor | HPMR | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK03 | P27361 | GABR1 | Q9UBS5 | Yes | No | Yes | SIGNOR | SIGNOR:37686242 |
| KCC2B | Q13554 | GABR1 | Q9UBS5 | Yes | No | Yes | SIGNOR | SIGNOR:37686242 |
| MK01 | P28482 | GABR1 | Q9UBS5 | Yes | No | Yes | SIGNOR | SIGNOR:37686242 |
| KINH | P33176 | GABR1 | Q9UBS5 | Yes | Yes | No | SIGNOR | SIGNOR:17532644 |
| KCC2A | Q9UQM7 | GABR1 | Q9UBS5 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:20643921SIGNOR:20643921 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA-B receptor | GABBR1GABBR2 | O75899Q9UBS5 | 1:1 | CORUMSIGNORComplexPortalPDB | PDB:4mr9PDB:4ms1PDB:6w2xPDB:4pasPDB:6uoaPDB:6uo9SIGNOR:SIGNOR-C336PDB:7c7qPDB:7cumCORUM:6437PDB:4ms4PDB:4mr8PDB:7ca3PDB:6wivPDB:4mr7intact:EBI-9212872PDB:4ms3PDB:6uo8PDB:7c7sPDB:7ca5PDB:4mqePDB:4mrmPDB:4mqfPDB:6vjm | 147552929872316 |
| GABBR1GABBR2NSF | O75899P46459Q9UBS5 | 1:1:1 | CompleatCFinder | Compleat:HC4228 | ||
| GABBR1GABBR2KCTD12KCTD16KCTD8 | O75899Q68DU8Q6ZWB6Q96CX2Q9UBS5 | 0:0:0:0:0 | Cellinker | |||
| GABBR1 | Q9UBS5 | 2 | PDB | PDB:6w2y |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
961
Mass
108,320
Sequence
MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Isoforms corresponding to the full receptor are essentially found in the central nervous system (CNS).; Name=1A; IsoId=Q9UBS5-1; Sequence=Displayed; Name=1B; IsoId=Q9UBS5-2; Sequence=VSP_002037; Name=1C; IsoId=Q9UBS5-3; Sequence=VSP_002038; Name=1D; IsoId=Q9UBS5-4; Sequence=VSP_002040; Name=1E; Synonyms=Truncated; IsoId=Q9UBS5-5; Sequence=VSP_002039
Alternative Sequence
1..164; MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPH -> MGPGAPFARVGWPLPLLVVMAAGVAPVWASHSPHLPRPHSRVPPHPS (in isoform 1B); 98..159; Missing (in isoform 1C); 570..961; GGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK -> VISRTHSPT (in isoform 1E); 905..961; KEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK -> SGGLPRGPPEPPDRLSCDGSRVHLLYK (in isoform 1D)
3D Structural Models
Turn
68..70; 203..205; 277..279; 462..466; 529..531; 555..558; 616..618; 651..653; 656..658; 859..861
Helix
185..200; 222..233; 247..256; 257..260; 272..275; 290..292; 293..303; 317..332; 348..356; 368..381; 400..402; 412..419; 443..453; 458..460; 467..484; 495..497; 504..514; 569..571; 589..615; 627..648; 659..692; 707..731; 766..790; 802..825; 826..828; 830..858; 885..917
Beta Strand
37..42; 51..53; 62..67; 73..75; 79..81; 83..89; 168..176; 178..181; 209..217; 234..237; 240..243; 263..268; 283..287; 308..316; 336..345; 361..365; 385..387; 389..393; 423..427; 454..456; 517..520; 523..526; 536..543; 546..554; 559..562; 580..584; 619..625; 735..740; 749..751; 753..762; 797..799
3D Structure
Electron microscopy (13); NMR spectroscopy (1); X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
868..880; Polar residues; 929..944; Pro residues
Coiled Coil
869..925
Domain (CC)
Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR2 (PubMed:9872744). The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably plays a role in the specificity for G-protein coupling (PubMed:9844003).
Domain (FT)
30..96; Sushi 1; 98..159; Sushi 2
Region
867..892; Disordered; 888..916; Interaction with ATF4; 909..961; Disordered
Protein Families
- G-protein coupled receptor 3 family
- GABA-B receptor subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targetsIntellectual disability
Drug Targets
FDA approved drug targets
Drugs
Antibody
Interaction Protein
ENSG00000136928ENSG00000170775
Interaction Count
2
Interaction Dataset
intact_biogrid