Protein detail
BIN2
Bridging integrator 2 (Breast cancer-associated protein 1)
Protein symbol BIN2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Bridging integrator 2 (Breast cancer-associated protein 1)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
BRAP-1
Gene Description
Bridging integrator 2
Chromosome
12
Position
51281038-51324668
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecifictestisCell SpecificAdipocytesSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AMPHBIN1BIN2LSM8 | O00499O95777P49418Q9UBW5 | 0:0:0:0 | hu.MAP2 | |||
| AMPHBIN1BIN2 | O00499P49418Q9UBW5 | 0:0:0 | hu.MAP2 | |||
| BIN2EXO5HSPA13IMPA2POLEPOLE2POLE3POLE4RAD17 | O14732O75943P48723P56282Q07864Q9H790Q9NR33Q9NRF9Q9UBW5 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9195 | ||
| BIN2BPNT2EXO5HSPA13POLEPOLE2POLE3POLE4RAD17UBC | O75943P0CG48P48723P56282Q07864Q9H790Q9NR33Q9NRF9Q9NX62Q9UBW5 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7795 | ||
| AMPHBIN2TBC1D1TBC1D14TIMM21UBC | P0CG48P49418Q86TI0Q9BVV7Q9P2M4Q9UBW5 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8503 | ||
| BIN2 | Q9UBW5 | 2 | PDB | PDB:4i1q |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [MALDI TOF]|Mass spectrometry [QTOF]|Western blottingMass spectrometry | 1 | 30915084 |
Sequence, Structure & Domains
Sequences
Length
565
Mass
61,874
Sequence
MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UBW5-1; Sequence=Displayed; Name=2; IsoId=Q9UBW5-2; Sequence=VSP_021328; Name=3; IsoId=Q9UBW5-3; Sequence=VSP_059731
Alternative Sequence
1..27; MAEGKAGGAAGLFAKQVQKKFSRAQEK -> M (in isoform 3); 105..136; Missing (in isoform 2)
3D Structural Models
Helix
16..31; 41..88; 96..120; 122..130; 132..160; 167..200; 202..241
Beta Strand
161..164
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
267..296; Low complexity; 376..385; Polar residues; 422..451; Low complexity; 453..465; Polar residues; 471..486; Basic and acidic residues; 487..507; Polar residues; 511..524; Basic and acidic residues; 526..549; Polar residues; 556..565; Polar residues
Coiled Coil
304..329
Domain (CC)
The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Domain (FT)
28..244; BAR
Region
267..565; Disordered