Protein detail

BIN2

Bridging integrator 2 (Breast cancer-associated protein 1)

Entry name BIN2	UniProt ID Q9UBW5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Bridging integrator 2 (Breast cancer-associated protein 1)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000110934

Entrez Gene Symbol

BIN2

Gene Synonym

BRAP-1

Gene Description

Bridging integrator 2

Chromosome

Position

51281038-51324668

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecifictestisCell SpecificAdipocytesSingle-Nuclei Brain Specificependymal cell

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (9)

Molecular Function (2)

Biological Process (3)

Reactome (5)

Canonical Pathways (3)

M3468 Naba ecm regulators
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence15

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AMPH BIN1 BIN2 LSM8	O00499 O95777 P49418 Q9UBW5	0:0:0:0	hu.MAP2
AMPH BIN1 BIN2	O00499 P49418 Q9UBW5	0:0:0	hu.MAP2
BIN2 EXO5 HSPA13 IMPA2 POLE POLE2 POLE3 POLE4 RAD17	O14732 O75943 P48723 P56282 Q07864 Q9H790 Q9NR33 Q9NRF9 Q9UBW5	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9195
BIN2 BPNT2 EXO5 HSPA13 POLE POLE2 POLE3 POLE4 RAD17 UBC	O75943 P0CG48 P48723 P56282 Q07864 Q9H790 Q9NR33 Q9NRF9 Q9NX62 Q9UBW5	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7795
AMPH BIN2 TBC1D1 TBC1D14 TIMM21 UBC	P0CG48 P49418 Q86TI0 Q9BVV7 Q9P2M4 Q9UBW5	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8503
BIN2	Q9UBW5	2	PDB	PDB:4i1q

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry [MALDI TOF]\|Mass spectrometry [QTOF]\|Western blottingMass spectrometry	1	30915084

Sequence, Structure & Domains13

Sequences

Length

565

Mass

61,874

Sequence

MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UBW5-1; Sequence=Displayed; Name=2; IsoId=Q9UBW5-2; Sequence=VSP_021328; Name=3; IsoId=Q9UBW5-3; Sequence=VSP_059731

Alternative Sequence

1..27; MAEGKAGGAAGLFAKQVQKKFSRAQEK -> M (in isoform 3); 105..136; Missing (in isoform 2)

3D Structural Models

Helix

16..31; 41..88; 96..120; 122..130; 132..160; 167..200; 202..241

Beta Strand

161..164

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

267..296; Low complexity; 376..385; Polar residues; 422..451; Low complexity; 453..465; Polar residues; 471..486; Basic and acidic residues; 487..507; Polar residues; 511..524; Basic and acidic residues; 526..549; Polar residues; 556..565; Polar residues

Coiled Coil

304..329

Domain (CC)

The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.

Domain (FT)

28..244; BAR

Region

267..565; Disordered

Clinical Relevance4

Antibody (2)

HPA038666 HPA038667

Interaction Protein

ENSG00000136717

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32141557	Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.	Eight pseudogenes, including Tropomyosin 1 (Alpha) Pseudogene (LOC100129096), Prothymosin, Alpha Pseudogene 2 (PTMAP2), Cell Division Cycle 14C, Pseudogene (CDC14C), Tropomyosin 1 (Alpha) Pseudogene (LOC643634), Ferritin Heavy Chain 1 Pseudogene 2 (FTH1P2), Actin Related Protein 2/3 Complex Subunit 3 Pseudogene 3 (ARPC3P3), Ferritin Heavy Chain 1 Pseudogene 11 (FTH1P11), and Prothymosin Alpha Pseudogene 5 (PTMAP5) were identified from plasma-derived exosomes in lung adenocarcinoma patients, who were more abundant/detectable than healthy volunteers.