Protein detail
FBLN5
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
Entry name FBLN5 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 12 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
Protein Class (5)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
ARMD3DANCEEVECUP50
Gene Description
Fibulin 5
Chromosome
14
Position
91869411-91947987
Supporting publications (n)
12
EVMP confidence score
0.60
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificErythrocyte progenitors
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Canonical Pathways
M255 Pid hif1 tfpathway
Mediation Categories (3)
Adhesion and uptake mediationImmune mediationMetabolism mediation
Relations & Evidence18
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| fibulin | ecm | HGNC | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | Yes | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | No | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FBN1 | P35555 | FBLN5 | Q9UBX5 | Yes | No | Yes | SIGNOR | SIGNOR:19570982 |
| FBLN5 | Q9UBX5 | ELN | P15502 | Yes | Yes | No | Lit-BM-17SIGNORIntAct | Lit-BM-17:19570982SIGNOR:19570982SIGNOR:18267938IntAct:19570982 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 27863537 |
Sequence, Structure & Domains8
Sequences
Length
448
Mass
50,180
Sequence
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
Domain & Motif Annotations
Motif
54..56; Cell attachment site
Domain (FT)
42..82; EGF-like 1; calcium-binding; 127..167; EGF-like 2; calcium-binding; 168..206; EGF-like 3; calcium-binding; 207..246; EGF-like 4; calcium-binding; 247..287; EGF-like 5; calcium-binding; 288..333; EGF-like 6; calcium-binding
Region
245..448; Interaction with LOXL1
Protein Families
Fibulin family
Sequence Similarities
Belongs to the fibulin family.
Clinical Relevance5
Supporting Publications11
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 29436780 | Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32295833 | Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. | Notably, mTau exosomes (not control exosomes) contain ANP32A (also known as I1PP2A), an endogenous inhibitor of the PP2A phosphatase which regulates the phosphorylation state of p-Tau. |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |
| 36797805 | Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No abstract available |
| 39537956 | Apoptosis-induced exosomes from human exfoliated deciduous teeth enhance angiogenesis in human umbilical vein endothelial cells. | No abstract available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No abstract available |
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