Protein detail
FBLN5
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
Protein symbol FBLN5 | UniProt ID | EVMP score 0.60 |
Frequency 12 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
ARMD3DANCEEVECUP50
Gene Description
Fibulin 5
Chromosome
14
Position
91869411-91947987
Frequency
12
EVMP Score
0.60
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificErythrocyte progenitors
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M255 Pid hif1 tfpathway
Mediation Categories
Adhesion and uptake mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| fibulin | ecm | HGNC | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | Yes | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | No | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FBN1 | P35555 | FBLN5 | Q9UBX5 | Yes | No | Yes | SIGNOR | SIGNOR:19570982 |
| FBLN5 | Q9UBX5 | ELN | P15502 | Yes | Yes | No | Lit-BM-17SIGNORIntAct | Lit-BM-17:19570982SIGNOR:19570982SIGNOR:18267938IntAct:19570982 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 27863537 |
Sequence, Structure & Domains
Sequences
Length
448
Mass
50,180
Sequence
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
3D Structural Models
Domain & Motif Annotations
Motif
54..56; Cell attachment site
Domain (FT)
42..82; EGF-like 1; calcium-binding; 127..167; EGF-like 2; calcium-binding; 168..206; EGF-like 3; calcium-binding; 207..246; EGF-like 4; calcium-binding; 247..287; EGF-like 5; calcium-binding; 288..333; EGF-like 6; calcium-binding
Region
245..448; Interaction with LOXL1
Protein Families
Fibulin family
Sequence Similarities
Belongs to the fibulin family.