Protein detail
LPAR3
Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)
Entry name LPAR3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)
Protein Function (2)
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..52; Helical; Name=1; 68..88; Helical; Name=2; 102..124; Helical; Name=3; 147..167; Helical; Name=4; 187..207; Helical; Name=5; 241..261; Helical; Name=6; 277..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Cell SpecificAdipocytesBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway7
Protein Function (2)
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (5)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence63
Ligand-Receptor Signaling (52)
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| lysophosphatidic_acid | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network (10)
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LPAR3 | Q9UBY5 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA12 | Q03113 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:15856019SIGNOR:22863277 |
| LPAR3 | Q9UBY5 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:11093753SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA13 | Q14344 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:15856019SIGNOR:22863277 |
| LPAR3 | Q9UBY5 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAQ | P50148 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:12531543SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA15 | P30679 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | ELISA | 1 | 37322475 |
Sequence, Structure & Domains5
Sequences
Length
353
Mass
40,128
Sequence
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance3
Related Diseases (2)
Biomarker
Phase 2
Drugs (2)
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 36114323 | Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment. | No abstract available |
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No abstract available |