Protein detail
DNJB4
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Entry name DNJB4 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HLJ1
Gene Description
DnaJ heat shock protein family (Hsp40) member B4
Chromosome
1
Position
77979175-78017964
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificNeutrophilsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence12
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster190 | DNAJB1DNAJB2DNAJB4DNAJB5DNAJB6DNAJB7DNAJB8 | O75190O75953P25685P25686Q7Z6W7Q8NHS0Q9UDY4 | 1:1:1:1:1:1:1 | Compleat | Compleat:HC1246 | 22036573 |
| DNAJB1DNAJB4DNAJB5SYNM | O15061O75953P25685Q9UDY4 | 0:0:0:0 | hu.MAP2 | |||
| DNAJB4DNAJB5DNAJC7SYNM | O15061O75953Q99615Q9UDY4 | 0:0:0:0 | hu.MAP | |||
| DNAJB4SYNM | O15061Q9UDY4 | 0:0 | hu.MAP | |||
| AHSA1DNAJB4 | O95433Q9UDY4 | 0:0 | Havugimana2012 | Havugimana2012:C_11 | ||
| DNAJB1DNAJB4 | P25685Q9UDY4 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
337
Mass
37,807
Sequence
MGKDYYCILGIEKGASDEDIKKAYRKQALKFHPDKNKSPQAEEKFKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFFGGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPVIHELRVSLEEIYSGCTKRMKISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS
Domain & Motif Annotations
Domain (FT)
2..70; J
Clinical Relevance
Disease Involvement
Disease variant
Interaction Protein (8)
ENSG00000100304ENSG00000109971ENSG00000112208ENSG00000120694ENSG00000132002ENSG00000137094ENSG00000170606ENSG00000204390
Interaction Count
8
Interaction Dataset (3)
biogrid_bioplexbiogrid_opencell_bioplexbiogrid_opencell
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37704750 | Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice. | No related sentences available |