Protein detail

ADDG

Gamma-adducin (Adducin-like protein 70)

Entry name ADDG	UniProt ID Q9UEY8	EVMP confidence score 0.72
Supporting publications (n) 16	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Gamma-adducin (Adducin-like protein 70)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Ensembl

ENSG00000148700

Entrez Gene Symbol

ADD3

Gene Synonym

ADDL

Gene Description

Adducin 3

Chromosome

Position

109996368-110135565

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization3

Tissue Specificblood vesselCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificastrocyte

Function & Pathway7

Protein Function (3)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Cellular Component (9)

Molecular Function (4)

Biological Process (3)

Reactome (6)

Canonical Pathways

M286 Pid tgfbr pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence22

Enzyme-Mediated Modification (12)

12 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ADD3	PRKACA	P17612	S	693	phosphorylation	KEA	KEA:9607561
ADD3	RPS6KA3	P51812	S	693	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCA	P17252	ADDG	Q9UEY8	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	HPRD-phos:11895774 HPRD:11895774 HPRD-phos:18452278 SIGNOR:11895774 ProtMapper:19651622 ProtMapper:20166139 ProtMapper:20068231 HPRD-phos:20068231 HPRD-phos:18669648 ProtMapper:11895774 ProtMapper:18669648 ProtMapper:18452278 KEA:9607561 HPRD-phos:19651622 KEA:11895774 HPRD-phos:20166139

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ADD3 ANKRD29	Q8N6D5 Q9UEY8	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	31414377

Sequence, Structure & Domains10

Sequences

Length

706

Mass

79,155

Sequence

MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQGLEDAEQELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=2; Synonyms=Long; IsoId=Q9UEY8-1; Sequence=Displayed; Name=1; Synonyms=Short; IsoId=Q9UEY8-2; Sequence=VSP_000188

Alternative Sequence

576..607; Missing (in isoform 1)

Domain & Motif Annotations

Compositional Bias

1..10; Polar residues; 589..602; Low complexity; 682..706; Basic residues

Domain (CC)

Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Region

1..20; Disordered; 471..497; Disordered; 535..555; Disordered; 575..610; Disordered; 666..706; Disordered; 684..701; Interaction with calmodulin

Protein Families (2)

Aldolase class II family
Adducin subfamily

Sequence Similarities

Belongs to the aldolase class II family. Adducin subfamily.

Clinical Relevance3

Disease Involvement

Disease variant

Drugs (19)

DIM ZQ-16 GLPG1205 UNDECANOIC ACID 2-HYDROXY CAPRIC ACID LAURIC ACID 3-HYDROXY CAPRIC ACID 2-HYDROXYLAURIC ACID PSB-1584 PSB-17365 EMBELIN PSB-16434 PBI-4547 DL-175 3-HYDROXYLAURIC ACID DECANOIC ACID 6-N-OCTYLAMINOURACIL SETOGEPRAM 6-NONYLPYRIDINE-2,4-DIOL

Antibody (2)

CAB009797 HPA035696

Supporting Publications16

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
33309826	Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
37926756	Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available

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