Protein detail

RIM3A

RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1)

Entry name RIM3A	UniProt ID Q9UFD9	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000275793

Entrez Gene Symbol

RIMBP3

Gene Synonym (3)

KIAA1666RIMBP3.1RIMBP3A

Gene Description

RIMS binding protein 3

Chromosome

Position

18605815-18611919

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Cell SpecificEsophageal apical cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Inhibition	Database	References
RIM3A	Q9UFD9	RIMS2	Q9UQ26	Yes	Yes	SIGNOR	SIGNOR:11988172
RIM3A	Q9UFD9	RIMS1	Q86UR5	Yes	Yes	SIGNOR	SIGNOR:11988172
RIM3A	Q9UFD9	RIMS3	Q9UJD0	Yes	Yes	SIGNOR	SIGNOR:11988172

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HOOK2-KCL3-LRGUK1-RIMBP3 complex	HOOK2 KLC3 LRGUK RIMBP3	Q6P597 Q96ED9 Q96M69 Q9UFD9	0:0:0:0	CORUM	CORUM:7445	28003339

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	35611462 39505756

Sequence, Structure & Domains

Sequences

Length

1,639

Mass

180,717

Sequence

MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH

3D Structural Models

Turn

1582..1585; 1628..1630

Beta Strand

1572..1578; 1589..1591; 1602..1607; 1614..1621; 1623..1627; 1631..1633

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

326..339; Pro residues; 707..718; Polar residues; 761..775; Polar residues; 776..790; Low complexity; 1293..1305; Polar residues

Coiled Coil

21..143; 409..442; 480..619

Domain (FT)

832..899; SH3 1; 995..1083; Fibronectin type-III 1; 1088..1184; Fibronectin type-III 2; 1452..1520; SH3 2; 1569..1636; SH3 3

Region

1..22; Disordered; 215..240; Disordered; 295..364; Disordered; 697..811; Disordered; 1251..1273; Disordered; 1292..1330; Disordered

Protein Families

RIMBP family

Sequence Similarities

Belongs to the RIMBP family.

Clinical Relevance

Antibody

HPA001183

Interaction Protein

ENSG00000131791

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Related sentences
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No related sentences available