Protein detail
S23A2
Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
Entry name S23A2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
111..131; Helical; 140..160; Helical; 162..182; Helical; 219..239; Helical; 267..284; Helical; 310..330; Helical; 372..392; Helical; 418..438; Helical; 462..482; Helical; 486..506; Helical; 517..537; Helical; 548..568; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
KIAA0238SLC23A1SVCT2YSPL2
Gene Description
Solute carrier family 23 member 2
Chromosome
20
Position
4852356-5010293
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue SpecificcervixCell SpecificBasal keratinocytesSingle-Nuclei Brain SpecificoligodendrocyteSecretome LocationIntracellular and membraneSecretome FunctionTransport
Function & Pathway6
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence28
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
Page 3 of 3Previous
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 40595564 |
Sequence, Structure & Domains9
Sequences
Length
650
Mass
70,337
Sequence
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGH3-1; Sequence=Displayed; Name=2; IsoId=Q9UGH3-2; Sequence=VSP_056485
Alternative Sequence
162..275; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..20; Polar residues
Region
1..21; Disordered
Protein Families
Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family
Sequence Similarities
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
Clinical Relevance4
Related Diseases (3)
Biomarker
Approved; Phase 2
Drugs (2)
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |