Protein detail

SWP70

Switch-associated protein 70 (SWAP-70)

Entry name SWP70	UniProt ID Q9UH65	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Switch-associated protein 70 (SWAP-70)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000133789

Entrez Gene Symbol

SWAP70

Gene Synonym (2)

KIAA0640SWAP-70

Gene Description

Switching B cell complex subunit SWAP70

Chromosome

Position

9664077-9752993

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (6)

Biological Process (3)

Reactome (5)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence11

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SWAP70	SYK	P43405	Y	517	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:21123826

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
SWAP complex	CLEC2D NCL NPM1 PARP1 SWAP70	P06748 P09874 P19338 Q9UH65 Q9UHP7	1:1:1:1:1	Compleat	Compleat:HC960	9642267
	PRPS1 PRPS2 RMC1 SWAP70	P11908 P60891 Q96DM3 Q9UH65	0:0:0:0	Havugimana2012	Havugimana2012:C_383
	RMC1 STAT5B STK32C SWAP70	P51692 Q86UX6 Q96DM3 Q9UH65	0:0:0:0	Havugimana2012	Havugimana2012:C_297

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	4	30550287 37686366 37922300 38136601

Sequence, Structure & Domains9

Sequences

Length

585

Mass

68,998

Sequence

MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE

3D Structural Models

Helix

291..310

Beta Strand

212..220; 227..234; 239..244; 248..254; 261..265; 273..278; 283..287

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Coiled Coil

316..539

Domain (CC)

The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.

Domain (FT)

210..306; PH

Clinical Relevance1

Antibody (2)

HPA006810 HPA006929

Supporting Publications1

PMID	Title	Abstract
36550367	Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays.	No abstract available