Protein detail
SWP70
Switch-associated protein 70 (SWAP-70)
Entry name SWP70 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Switch-associated protein 70 (SWAP-70)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0640SWAP-70
Gene Description
Switching B cell complex subunit SWAP70
Chromosome
11
Position
9664077-9752993
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SWAP70 | SYK | P43405 | Y | 517 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:21123826 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SWAP complex | CLEC2DNCLNPM1PARP1SWAP70 | P06748P09874P19338Q9UH65Q9UHP7 | 1:1:1:1:1 | Compleat | Compleat:HC960 | 9642267 |
| PRPS1PRPS2RMC1SWAP70 | P11908P60891Q96DM3Q9UH65 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_383 | ||
| RMC1STAT5BSTK32CSWAP70 | P51692Q86UX6Q96DM3Q9UH65 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_297 |
Sequence, Structure & Domains
Sequences
Length
585
Mass
68,998
Sequence
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
3D Structural Models
Helix
291..310
Beta Strand
212..220; 227..234; 239..244; 248..254; 261..265; 273..278; 283..287
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Coiled Coil
316..539
Domain (CC)
The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
Domain (FT)
210..306; PH