Protein detail
LIMA1
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Entry name LIMA1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 14 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
EPLIN
Gene Description
LIM domain and actin binding 1
Chromosome
12
Position
50175788-50283520
Supporting publications (n)
14
EVMP confidence score
0.72
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence18
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LIMA1 | MAPK1 | P28482 | S | 604 | phosphorylation | SIGNOR | SIGNOR:23188829 |
| LIMA1 | MAPK1 | P28482 | S | 362 | phosphorylation | SIGNOR | SIGNOR:23188829 |
| LIMA1 | MAPK3 | P27361 | S | 604 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | MAPK3 | P27361 | S | 374 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | MAPK3 | P27361 | S | 362 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | CAMK2D | Q13557 | S | 132 | phosphorylation | PhosphoNetworks | |
| LIMA1 | CAMK2D | Q13557 | S | 369 | phosphorylation | PhosphoNetworks | |
| LIMA1 | CAMK2D | Q13557 | T | 592 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK01 | P28482 | LIMA1 | Q9UHB6 | Yes | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:23188829ProtMapper:23188829 | |
| MK03 | P27361 | LIMA1 | Q9UHB6 | Yes | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28465438 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
759
Mass
85,226
Sequence
MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE
Alternative Products
Event=Alternative promoter usage, Alternative splicing; Named isoforms=5; Name=Beta; IsoId=Q9UHB6-1; Sequence=Displayed; Name=Alpha; IsoId=Q9UHB6-2; Sequence=VSP_003116; Name=3; IsoId=Q9UHB6-3; Sequence=VSP_003117; Name=4; IsoId=Q9UHB6-4; Sequence=VSP_040136; Name=5; IsoId=Q9UHB6-5; Sequence=VSP_003116, VSP_040136
Alternative Sequence
1..302; Missing (in isoform 3); 1..160; Missing (in isoform Alpha and isoform 5); 344; R -> PG (in isoform 4 and isoform 5)
3D Structural Models
Turn
391..393; 412..414; 418..420; 426..428
Helix
439..445
Beta Strand
384..387; 401..404; 406..411; 432..434
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
96..105; Basic and acidic residues; 146..177; Basic and acidic residues; 247..258; Basic and acidic residues; 362..376; Low complexity; 516..527; Basic and acidic residues; 556..567; Basic and acidic residues; 595..607; Polar residues; 644..655; Polar residues; 656..673; Basic and acidic residues; 674..691; Acidic residues; 693..709; Polar residues
Motif
164..166; Required for interaction with NPC1L1
Domain (CC)
Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
Domain (FT)
388..448; LIM zinc-binding
Region
78..131; Disordered; 146..182; Disordered; 211..264; Disordered; 323..381; Disordered; 493..513; Required for interaction with MYO5B; 509..709; Disordered
Clinical Relevance
Supporting Publications14
| PMID | Title | Related sentences |
|---|---|---|
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No related sentences available |
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No related sentences available |
| 30178811 | Effect of exercise on the plasma vesicular proteome: a methodological study comparing acoustic trapping and centrifugation. | No related sentences available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No related sentences available |
| 34064677 | Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 35119778 | Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. | No related sentences available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
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