Protein detail
LIMA1
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Protein symbol LIMA1 | UniProt ID | EVMP score 0.72 |
Frequency 14 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
EPLIN
Gene Description
LIM domain and actin binding 1
Chromosome
12
Position
50175788-50283520
Frequency
14
EVMP Score
0.72
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LIMA1 | MAPK1 | P28482 | S | 604 | phosphorylation | SIGNOR | SIGNOR:23188829 |
| LIMA1 | MAPK1 | P28482 | S | 362 | phosphorylation | SIGNOR | SIGNOR:23188829 |
| LIMA1 | MAPK3 | P27361 | S | 604 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | MAPK3 | P27361 | S | 374 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | MAPK3 | P27361 | S | 362 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LIMA1 | CAMK2D | Q13557 | S | 132 | phosphorylation | PhosphoNetworks | |
| LIMA1 | CAMK2D | Q13557 | S | 369 | phosphorylation | PhosphoNetworks | |
| LIMA1 | CAMK2D | Q13557 | T | 592 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK01 | P28482 | LIMA1 | Q9UHB6 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:23188829ProtMapper:23188829 |
| MK03 | P27361 | LIMA1 | Q9UHB6 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:28465438 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
759
Mass
85,226
Sequence
MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE
Alternative Products
Event=Alternative promoter usage, Alternative splicing; Named isoforms=5; Name=Beta; IsoId=Q9UHB6-1; Sequence=Displayed; Name=Alpha; IsoId=Q9UHB6-2; Sequence=VSP_003116; Name=3; IsoId=Q9UHB6-3; Sequence=VSP_003117; Name=4; IsoId=Q9UHB6-4; Sequence=VSP_040136; Name=5; IsoId=Q9UHB6-5; Sequence=VSP_003116, VSP_040136
Alternative Sequence
1..302; Missing (in isoform 3); 1..160; Missing (in isoform Alpha and isoform 5); 344; R -> PG (in isoform 4 and isoform 5)
3D Structural Models
Turn
391..393; 412..414; 418..420; 426..428
Helix
439..445
Beta Strand
384..387; 401..404; 406..411; 432..434
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
96..105; Basic and acidic residues; 146..177; Basic and acidic residues; 247..258; Basic and acidic residues; 362..376; Low complexity; 516..527; Basic and acidic residues; 556..567; Basic and acidic residues; 595..607; Polar residues; 644..655; Polar residues; 656..673; Basic and acidic residues; 674..691; Acidic residues; 693..709; Polar residues
Motif
164..166; Required for interaction with NPC1L1
Domain (CC)
Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
Domain (FT)
388..448; LIM zinc-binding
Region
78..131; Disordered; 146..182; Disordered; 211..264; Disordered; 323..381; Disordered; 493..513; Required for interaction with MYO5B; 509..709; Disordered