Protein detail
NPCL1
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1)
Protein symbol NPCL1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 13 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1)
Protein Class
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
285..305; Helical; Name=1; 352..372; Helical; Name=2; 633..653; Helical; Name=3; 667..687; Helical; Name=4; 697..717; Helical; Name=5; 743..763; Helical; Name=6; 777..797; Helical; Name=7; 847..867; Helical; Name=8; 1140..1160; Helical; Name=9; 1169..1189; Helical; Name=10; 1192..1212; Helical; Name=11; 1237..1257; Helical; Name=12; 1269..1289; Helical; Name=13
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
Gene Synonym
SLC65A2
Gene Description
NPC1 like intracellular cholesterol transporter 1
Chromosome
7
Position
44512535-44541330
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARCN1ARF4COPACOPB1COPB2COPG1LMAN2NPC1L1SEC23ASURF4TMED10TMED2TMED7TMED9UBC | O15260P0CG48P18085P35606P48444P49755P53618P53621Q12907Q15363Q15436Q9BVK6Q9UHC9Q9Y3B3Q9Y678 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9054 | ||
| NPC1L1 | Q9UHC9 | 2 | PDB | PDB:7n4uPDB:7n4v |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 35655072 |
Sequence, Structure & Domains
Sequences
Length
1,359
Mass
148,728
Sequence
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UHC9-1; Sequence=Displayed; Name=2; Synonyms=NPC1L1DELTAE15; IsoId=Q9UHC9-2; Sequence=VSP_015314; Name=3; Synonyms=NPCL1T; IsoId=Q9UHC9-3; Sequence=VSP_015312, VSP_015313; Name=4; IsoId=Q9UHC9-4; Sequence=VSP_054503, VSP_015314
Alternative Sequence
723..724; RL -> GP (in isoform 3); 725..1359; Missing (in isoform 3); 850..895; Missing (in isoform 4); 1046..1072; Missing (in isoform 2 and isoform 4)
3D Structural Models
Turn
110..112; 209..212; 248..250; 256..258; 459..461; 608..610; 630..632; 647..649; 660..663; 802..805; 941..943; 1029..1031
Helix
68..77; 79..81; 93..109; 114..129; 133..135; 162..172; 186..188; 199..206; 225..228; 260..262; 335..350; 352..367; 380..382; 389..401; 438..452; 467..470; 482..484; 490..494; 498..501; 518..527; 552..554; 564..566; 585..606; 620..625; 633..636; 638..646; 657..659; 666..689; 696..723; 732..761; 767..798; 828..832; 833..840; 843..863; 864..866; 873..876; 883..893; 913..917; 930..938; 953..960; 1005..1017; 1086..1107; 1126..1129; 1131..1133; 1135..1156; 1162..1185; 1192..1204; 1206..1217; 1224..1252; 1253..1256; 1260..1265; 1268..1282; 1285..1291; 1298..1300; 1301..1312
Beta Strand
34..40; 47..49; 55..58; 84..86; 88..90; 137..143; 146..149; 152..161; 194..196; 215..223; 370..373; 406..411; 420..423; 425..427; 429..432; 434..437; 455..458; 463..466; 474..476; 477..479; 487..489; 505..511; 513..516; 535..538; 545..548; 556..558; 560..562; 569..576; 614..616; 808..810; 877..880; 899..904; 921..924; 946..951; 961..978; 986..994; 998..1000; 1032..1038; 1040..1042; 1073..1080; 1119..1122
3D Structure
Electron microscopy (6); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
632..797; SSD
Protein Families
Patched family
Sequence Similarities
Belongs to the patched family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved
Drug Targets
FDA approved drug targets