Protein detail
LAT2
Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)
Entry name LAT2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
45..65; Helical; Name=1; 74..95; Helical; Name=2; 117..149; Helical; Name=3; 158..178; Helical; Name=4; 182..210; Helical; Name=5; 231..252; Helical; Name=6; 266..287; Helical; Name=7; 313..338; Helical; Name=8; 365..382; Helical; Name=9; 387..408; Helical; Name=10; 424..446; Helical; Name=11; 447..466; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
LAT2LPI-PC1
Gene Description
Solute carrier family 7 member 8
Chromosome
14
Position
23125295-23183674
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificliverCell SpecificAdipocytes
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (5)
Molecular Function (13)
- GO:0005515 protein binding
- GO:0015101 organic cation transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015180 L-alanine transmembrane transporter activity
- GO:0015187 glycine transmembrane transporter activity
- GO:0015190 L-leucine transmembrane transporter activity
- GO:0015297 antiporter activity
- GO:0015349 thyroid hormone transmembrane transporter activity
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Biological Process (3)
Reactome (6)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence22
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting | 1 | 35820407 |
Sequence, Structure & Domains13
Sequences
Length
535
Mass
58,382
Sequence
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UHI5-1; Sequence=Displayed; Name=2; IsoId=Q9UHI5-2; Sequence=VSP_046946; Name=3; IsoId=Q9UHI5-3; Sequence=VSP_046945; Name=4; IsoId=Q9UHI5-4; Sequence=VSP_046947
Alternative Sequence
1..263; MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYK -> MGQLFQCAVGHPGSRHLHSWEAPGLGPDYHHGDCTDMQR (in isoform 3); 1..203; Missing (in isoform 2); 1..169; MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICL -> MGQYGQELSWKCLVKAVCLQEHSQPSQLLCTLLLCWCVLGRERPFRKAQSTSSPLEGVPRFLKR (in isoform 4)
3D Structural Models
Turn
58..61; 103..105; 210..212; 242..245; 249..254; 336..338; 346..348
Helix
42..53; 62..69; 72..99; 106..112; 117..128; 130..146; 158..177; 180..185; 189..209; 231..233; 234..241; 255..257; 266..288; 293..296; 302..308; 314..335; 339..345; 365..377; 386..411; 426..444; 446..466; 474..490
Beta Strand
55..57; 147..154; 215..217; 258..260; 262..265; 357..361; 380..382
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
1..17; Basic and acidic residues; 514..523; Polar residues
Region
1..30; Disordered; 502..535; Disordered
Protein Families (2)
- Amino acid-polyamine-organocation (APC) superfamily
- L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Sequence Similarities
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.