Protein detail
S23A1
Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
Protein symbol S23A1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
53..73; Helical; 82..102; Helical; 104..124; Helical; 160..180; Helical; 208..225; Helical; 251..271; Helical; 313..333; Helical; 359..379; Helical; 403..423; Helical; 427..447; Helical; 458..478; Helical; 491..511; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
SVCT1 YSPL3
Gene Description
Solute carrier family 23 member 1
Chromosome
5
Position
139367196-139384553
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0008520 L-ascorbate:sodium symporter activity
- GO:0015081 sodium ion transmembrane transporter activity
- GO:0015143 urate transmembrane transporter activity
- GO:0015205 nucleobase transmembrane transporter activity
- GO:0015229 L-ascorbic acid transmembrane transporter activity
- GO:0033300 dehydroascorbic acid transmembrane transporter activity
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 35831551 |
Sequence, Structure & Domains
Sequences
Length
598
Mass
64,815
Sequence
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9UHI7-1; Sequence=Displayed; Name=2; IsoId=Q9UHI7-2; Sequence=VSP_006814; Name=3; IsoId=Q9UHI7-3; Sequence=VSP_006813
Alternative Sequence
92..430; Missing (in isoform 3); 156; V -> VGLHV (in isoform 2)
3D Structural Models
Turn
136..138; 180..182; 252..254; 290..293; 297..299; 308..311; 519..526
Helix
41..59; 61..69; 76..100; 112..122; 125..127; 132..135; 146..172; 176..179; 185..197; 200..207; 211..226; 256..273; 286..288; 318..345; 353..373; 383..392; 397..412; 414..420; 425..444; 445..449; 455..477; 479..481; 487..497; 500..514; 542..544; 550..553; 557..560
Beta Strand
108..110; 281..284; 379..381; 562..564
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
1..17; Basic and acidic residues; 588..598; Polar residues
Region
1..25; Disordered; 579..598; Disordered
Protein Families
Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family
Sequence Similarities
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Approved
Drugs
Antibody
Interaction Protein
ENSG00000187766
Interaction Count
1
Interaction Dataset
intact_biogrid