Protein detail

CEIP2

Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)

Protein symbol
CEIP2
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
EnzymesPredicted intracellular proteinsPredicted membrane proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cell surface hyaluronidase CEMIP2 (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)
Protein Class
EnzymesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Transmembrane
83..103; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Entrez Gene Symbol
Gene Synonym
TMEM2
Gene Description
Cell migration inducing hyaluronidase 2
Chromosome
9
Position
71683366-71816690
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

17 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
transmembranetransmembrane_predictedPhobiusNoNoNoNoNo
transmembrane_phobiustransmembrane_predictedAlmen2009NoNoNoNoNo
transmembrane_sosuitransmembrane_predictedAlmen2009NoNoNoNoNo
transmembrane_tmhmmtransmembrane_predictedAlmen2009NoNoNoNoNo
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Regulatory Interaction Network

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
MARH9Q86YJ5CEIP2Q9UHN6YesNoYesSIGNORSIGNOR:19457934

Protein Complex Composition

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CABCOCO1CEMIP2CHST3CRPPRSS23O95084P02741Q7LGC8Q8IVU9Q9UHN60:0:0:0:0hu.MAP2
CABCOCO1CEMIP2CHST3CRPP02741Q7LGC8Q8IVU9Q9UHN60:0:0:0hu.MAP2
CEMIP2CHST3CRPP02741Q7LGC8Q9UHN60:0:0hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationELISA137322475
Sequence, Structure & Domains

Sequences

Length
1,383
Mass
154,374
Sequence
MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHN6-1; Sequence=Displayed; Name=2; IsoId=Q9UHN6-2; Sequence=VSP_041401
Alternative Sequence
402..464; Missing (in isoform 2)

3D Structural Models

Turn
274..276; 287..289; 357..360; 508..510; 559..562; 632..634; 655..658; 935..937; 982..985; 1090..1092; 1123..1126; 1171..1174; 1299..1308; 1342..1344; 1358..1361
Helix
249..251; 293..302; 324..334; 339..341; 442..444; 637..640; 697..699; 708..710; 761..763; 943..946; 1107..1112; 1167..1170; 1220..1225; 1268..1272; 1273..1278; 1371..1378
Beta Strand
121..123; 127..135; 140..143; 147..154; 159..162; 166..168; 172..181; 186..190; 192..194; 200..204; 215..217; 219..224; 229..233; 240..245; 252..254; 257..262; 266..272; 279..285; 309..314; 319..321; 347..353; 362..366; 378..384; 390..400; 403..412; 416..422; 432..435; 446..451; 460..465; 474..476; 484..487; 491..496; 518..522; 527..533; 535..539; 541..543; 550..556; 568..571; 573..576; 581..589; 591..594; 596..602; 604..607; 616..619; 621..626; 629..631; 663..671; 673..676; 678..694; 716..735; 751..753; 772..781; 783..789; 791..798; 800..803; 805..810; 814..816; 818..821; 824..828; 830..834; 848..850; 852..854; 857..859; 861..863; 869..873; 878..882; 884..886; 897..901; 914..917; 949..959; 961..967; 979..981; 986..989; 993..1000; 1008..1012; 1015..1022; 1027..1030; 1037..1041; 1043..1051; 1054..1062; 1068..1074; 1080..1088; 1095..1100; 1114..1122; 1127..1133; 1143..1145; 1148..1157; 1210..1217; 1229..1235; 1237..1240; 1242..1253; 1258..1267; 1286..1293; 1321..1326; 1336..1339; 1347..1354
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Repeat
669..691; PbH1 1; 711..733; PbH1 2; 791..812; PbH1 3
Domain (FT)
121..245; G8; 255..412; GG-type lectin 1; 1208..1366; GG-type lectin 2
Region
1..50; Disordered
Protein Families
CEMIP family
Sequence Similarities
Belongs to the CEMIP family.
Clinical Relevance