Protein detail

CBPA4

Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)

Protein symbol CBPA4	UniProt ID Q9UI42	EVMP score 0.50
Frequency 10	Transmembrane count	Protein classification

Basic Information

Protein Names

Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)

Protein Function

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Ensembl

ENSG00000128510

Entrez Gene Symbol

CPA4

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificBergmann gliaSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificbasophil

Function & Pathway

Protein Function

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	No	No
m14_carboxypeptidase	secreted_peptidase	OmniPath	No	No	Yes	No	No
secreted_enzyme	secreted_enzyme	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted_peptidase	secreted_peptidase	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CAT CLYBL CPA4 QSOX1	O00391 P04040 Q8N0X4 Q9UI42	0:0:0:0	hu.MAP
CPA4 LXN	Q9BS40 Q9UI42	2:2	hu.MAP2PDB	PDB:2bo9
CPA4	Q9UI42	2	PDB	PDB:2boa

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	11	26826536 37926756 36064647 38113368 37322475 34064677 32560723 41307968 36146834 31805958 38207106

Sequence, Structure & Domains

Sequences

Length

421

Mass

47,351

Sequence

MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI42-1; Sequence=Displayed; Name=2; IsoId=Q9UI42-2; Sequence=VSP_042894

Alternative Sequence

96..128; Missing (in isoform 2)

3D Structural Models

Turn

44..47; 141..143; 202..204; 344..346

Helix

34..43; 48..50; 70..72; 73..82; 94..115; 126..139; 185..201; 206..214; 225..233; 255..257; 286..298; 328..343; 355..358; 366..372; 390..392; 395..397; 398..417

Beta Strand

25..29; 52..55; 59..62; 64..68; 87..92; 120..122; 144..151; 157..163; 173..178; 216..221; 249..251; 259..262; 265..270; 301..308; 310..317; 351..354; 377..382; 386..389

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)

122..416; Peptidase M14

Protein Families

Peptidase M14 family

Sequence Similarities

Belongs to the peptidase M14 family.

Clinical Relevance