Protein detail

CBPA4

Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)

Entry name CBPA4	UniProt ID Q9UI42	EVMP confidence score 0.50
Supporting publications (n) 10	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Ensembl

ENSG00000128510

Entrez Gene Symbol

CPA4

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificBergmann gliaSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificbasophil

Function & Pathway5

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Metabolism mediation

Relations & Evidence16

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	No	No
m14_carboxypeptidase	secreted_peptidase	OmniPath	No	No	Yes	No	No
secreted_enzyme	secreted_enzyme	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted_peptidase	secreted_peptidase	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CAT CLYBL CPA4 QSOX1	O00391 P04040 Q8N0X4 Q9UI42	0:0:0:0	hu.MAP
CPA4 LXN	Q9BS40 Q9UI42	2:2	hu.MAP2PDB	PDB:2bo9
CPA4	Q9UI42	2	PDB	PDB:2boa

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	11	26826536 37926756 36064647 38113368 37322475 34064677 32560723 41307968 36146834 31805958 38207106

Sequence, Structure & Domains12

Sequences

Length

421

Mass

47,351

Sequence

MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI42-1; Sequence=Displayed; Name=2; IsoId=Q9UI42-2; Sequence=VSP_042894

Alternative Sequence

96..128; Missing (in isoform 2)

3D Structural Models

Turn

44..47; 141..143; 202..204; 344..346

Helix

34..43; 48..50; 70..72; 73..82; 94..115; 126..139; 185..201; 206..214; 225..233; 255..257; 286..298; 328..343; 355..358; 366..372; 390..392; 395..397; 398..417

Beta Strand

25..29; 52..55; 59..62; 64..68; 87..92; 120..122; 144..151; 157..163; 173..178; 216..221; 249..251; 259..262; 265..270; 301..308; 310..317; 351..354; 377..382; 386..389

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)

122..416; Peptidase M14

Protein Families

Peptidase M14 family

Sequence Similarities

Belongs to the peptidase M14 family.

Supporting Publications10

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available
40089067	Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells.	No abstract available