Protein detail
CYH4
Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)
Entry name CYH4 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CYT4cytohesin-4PSCD4
Gene Description
Cytohesin 4
Chromosome
22
Position
37282027-37315341
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
KEGG (5)
Reactome (4)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence8
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath | |||||
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | |||
| tight_junction | tight_junction | OmniPath | Yes | Yes | |||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains
Sequences
Length
394
Mass
45,672
Sequence
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
Domain & Motif Annotations
Coiled Coil
12..65
Domain (CC)
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.; DOMAIN: Autoinhibited by its C-terminal basic region.
Domain (FT)
54..241; SEC7; 259..375; PH
Region
386..394; C-terminal autoinhibitory region
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |