Protein detail
SLAF5
SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
Protein symbol SLAF5 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
Basic Information
Protein Names
SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
Protein Class
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
226..246; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
hCD84mCD84SLAMF5
Gene Description
CD84 molecule
Chromosome
1
Position
160541095-160579516
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonuclei
Function & Pathway
Protein Function
CD markers
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD84 | LYN | P07948 | Y | 279 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22068234 |
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| slam | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 35988891 |
Sequence, Structure & Domains
Sequences
Length
345
Mass
38,782
Sequence
MAQHHLWILLLCLQTWPEAAGKDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKEEKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMGFRTHHTGLLSVLAMFFLLVLILSSVFLFRLFKRRQGRIFPEGSCLNTFTKNPYAASKKTIYTYIMASRNTQPAESRIYDEILQSKVLPSKEEPVNTVYSEVQFADKMGKASTQDSKPPGTSSYEIVI
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=CD84a; IsoId=Q9UIB8-1; Sequence=Displayed; Name=2; Synonyms=CD84b; IsoId=Q9UIB8-2; Sequence=VSP_020852; Name=3; Synonyms=CD84c; IsoId=Q9UIB8-3; Sequence=VSP_020851; Name=4; Synonyms=CD84e; IsoId=Q9UIB8-4; Sequence=VSP_020854, VSP_020856; Name=5; Synonyms=CD84d; IsoId=Q9UIB8-5; Sequence=VSP_020853, VSP_020855; Name=6; Synonyms=CD84s; IsoId=Q9UIB8-6; Sequence=VSP_020849, VSP_020850; Name=7; IsoId=Q9UIB8-7; Sequence=VSP_020848, VSP_020851
Alternative Sequence
16..130; WPEAAGKDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYR -> C (in isoform 7); 214..241; DIAMGFRTHHTGLLSVLAMFFLLVLILS -> GNQLCPSLLVSLRDHSEELQGLNVGHIL (in isoform 6); 242..345; Missing (in isoform 6); 254..271; GRIFPEGSCLNTFTKNPY -> D (in isoform 3 and isoform 7); 254..259; Missing (in isoform 2); 255..272; RIFPEGSCLNTFTKNPYA -> ASLQGRASEHSLFRSAVC (in isoform 5); 261..280; SCLNTFTKNPYAASKKTIYT -> KMWKLTFSPPGTEAIYPRFS (in isoform 4); 273..345; Missing (in isoform 5); 281..345; Missing (in isoform 4)
3D Structural Models
Turn
89..91
Helix
79..81; 101..103
Beta Strand
27..32; 37..39; 49..64; 68..70; 73..76; 85..87; 94..96; 105..115; 118..129
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
328..345; Polar residues
Motif
277..282; ITSM 1; 314..319; ITSM 2
Domain (CC)
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain (FT)
26..129; Ig-like V-type; 135..207; Ig-like C2-type
Region
326..345; Disordered
Clinical Relevance
Drugs