Protein detail
ZDHC2
Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)
Entry name ZDHC2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Transmembrane
17..37; Helical; 55..75; Helical; 171..191; Helical; 209..229; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
DHHC2ZNF372
Gene Description
Zinc finger DHHC-type palmitoyltransferase 2
Chromosome
8
Position
17156482-17224799
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0055038 recycling endosome membrane
- GO:0098837 postsynaptic recycling endosome
- GO:0098944 postsynaptic recycling endosome membrane
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
Reactome
- R-hsa-5663205 infectious disease
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9694548 maturation of sars cov 2 spike protein
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-5683826 surfactant metabolism
- R-hsa-9694635 translation of sars cov 2 structural proteins
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ZDHC2 | Q9UIJ5 | AKAP5 | P24588 | Yes | Yes | No | SIGNOR | SIGNOR:25589740 |
| ZDHC2 | Q9UIJ5 | DLG4 | P78352 | Yes | Yes | No | SIGNOR | SIGNOR:23836932 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
367
Mass
42,022
Sequence
MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQDPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPALTMENET
3D Structural Models
Domain & Motif Annotations
Compositional Bias
333..348; Polar residues
Motif
335..336; Non-canonical dileucine endocytic signal; 358..361; NPxY-like endocytic signal
Domain (CC)
The DHHC domain is required for palmitoyltransferase activity.
Domain (FT)
127..177; DHHC
Region
299..367; Mediates localization to plasma membrane and recycling endosomes; 330..367; Disordered
Protein Families
DHHC palmitoyltransferase family
Sequence Similarities
Belongs to the DHHC palmitoyltransferase family.