Protein detail
LCAP
Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]
Protein symbol LCAP | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification EnzymesPredicted membrane proteins |
Basic Information
Protein Names
Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]
Protein Class
EnzymesPredicted membrane proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
111..131; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CAPIRAPP-LAPPLAP
Gene Description
Leucyl and cystinyl aminopeptidase
Chromosome
5
Position
96935394-97037513
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificEndometrial glandular cells
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236977 endosomal vacuolar pathway
- R-hsa-199991 membrane trafficking
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
Sequence, Structure & Domains
Sequences
Length
1,025
Mass
117,349
Sequence
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9UIQ6-1; Sequence=Displayed; Name=2; IsoId=Q9UIQ6-2; Sequence=VSP_005448; Name=3; IsoId=Q9UIQ6-3; Sequence=VSP_005449
Alternative Sequence
1..19; Missing (in isoform 3); 1..14; Missing (in isoform 2)
3D Structural Models
Turn
185..188; 224..226; 295..298; 340..342; 447..449; 472..474; 848..850; 857..859; 970..973
Helix
238..240; 299..302; 356..358; 384..390; 391..408; 440..442; 452..468; 480..483; 484..501; 503..505; 508..522; 537..542; 546..562; 565..579; 586..597; 603..612; 694..696; 706..718; 720..722; 725..741; 746..753; 754..758; 762..782; 785..804; 814..829; 835..847; 860..867; 871..881; 887..897; 903..915; 921..923; 924..933; 935..947; 949..955; 961..969; 977..988; 992..995; 998..1024
Beta Strand
165..167; 170..184; 189..202; 204..210; 215..223; 229..231; 233..237; 242..251; 256..266; 268..280; 282..284; 286..293; 308..310; 313..322; 325..331; 333..338; 343..348; 353..355; 361..364; 367..373; 376..382; 415..424; 426..430; 435..439; 475..479; 523..526; 582..584; 600..602; 613..615; 617..624; 627..634; 654..662; 663..665; 667..674; 676..682; 687..693; 698..704; 742..744; 808..810; 917..919
3D Structure
X-ray crystallography (11)
Domain & Motif Annotations
Motif
53..54; Dileucine internalization motif; 76..77; Dileucine internalization motif
Region
96..101; Tankyrase binding
Protein Families
Peptidase M1 family
Sequence Similarities
Belongs to the peptidase M1 family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000107854ENSG00000127022
Interaction Count
2
Interaction Dataset
intact_biogridbiogrid_opencell