Protein detail
PLXA1
Plexin-A1 (Semaphorin receptor NOV)
Protein symbol PLXA1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Plexin-A1 (Semaphorin receptor NOV)
Protein Class
Disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Transmembrane
1245..1265; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
NOVPLXN1
Gene Description
Plexin A1
Chromosome
3
Position
126982693-127037389
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificAlveolar cells type 2Single-Nuclei Brain SpecificastrocyteBlood Cell SpecificNK-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-399956 crmps in sema3a signaling
- R-hsa-9675108 nervous system development
- R-hsa-416700 other semaphorin interactions
- R-hsa-9013405 rhod gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-399954 sema3a pak dependent axon repulsion
- R-hsa-399955 sema3a plexin repulsion signaling by inhibiting integrin adhesion
- R-hsa-373755 semaphorin interactions
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Adhesion and uptake mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEM3A | Q14563 | PLXA1 | Q9UIW2 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACEHPMR_talklr | Baccin2019:10520994HPMR:15121181LRdb:10520994HPMR:10520994SIGNOR:25335892connectomeDB2020:10520994CellTalkDB:10520994 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PLXNA1-RANBPM complex | PLXNA1RANBP9 | Q96S59Q9UIW2 | 1:1 | CompleatCORUM | Compleat:HC3569CORUM:5757 | 16672672 |
| PlexinA1_complex1 | KDRPLXNA1 | P35968Q9UIW2 | 1:1 | CellPhoneDBCellinkerICELLNETCellChatDB | CellPhoneDB:PlexinA1_complex1 | 19176370 |
| CHST10CNTNAP3GALNT13PLXNA1PTPRU | O43529Q8IUC8Q92729Q9BZ76Q9UIW2 | 0:0:0:0:0 | hu.MAP | |||
| MEGF8PLXNA1 | Q7Z7M0Q9UIW2 | 0:0 | hu.MAP | |||
| PLXNA1TREM2 | Q9NZC2Q9UIW2 | 0:0 | Cellinker |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
1,896
Mass
211,067
Sequence
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYESVVAQEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQLTVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESESVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNVSEDCPQILPSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLTVSETQLLCEAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDEILAALEKDEQARRQRLRSKLEQVVDTMALSS
3D Structural Models
Turn
58..60; 99..101; 122..125; 134..136; 143..145; 178..180; 195..197; 213..216; 386..389; 536..539; 544..546; 548..551; 630..634; 645..647; 681..684
Helix
156..158; 233..238; 321..328; 362..372; 374..377; 515..517; 521..524; 525..527; 560..562; 592..594; 622..629; 661..663; 667..671; 690..692; 696..698; 703..705
Beta Strand
42..45; 47..49; 51..56; 63..74; 80..85; 117..121; 126..130; 138..142; 166..168; 170..175; 183..188; 200..206; 218..220; 239..241; 244..252; 255..263; 265..268; 277..286; 296..304; 307..318; 336..346; 348..350; 355..361; 410..412; 424..432; 434..442; 445..452; 455..462; 471..481; 496..502; 504..512; 533..535; 540..542; 555..557; 565..574; 581..588; 596..600; 605..607; 609..611; 614..618; 635..644; 648..659; 672..675; 678..680; 685..689; 693..695
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Coiled Coil
1264..1317
Domain (FT)
27..512; Sema; 864..959; IPT/TIG 1; 961..1045; IPT/TIG 2; 1048..1147; IPT/TIG 3; 1150..1236; IPT/TIG 4
Protein Families
Plexin family
Sequence Similarities
Belongs to the plexin family.