Protein detail
NGAP
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Entry name NGAP | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Protein Class (3)
Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
nGAP
Gene Description
RAS protein activator like 2
Chromosome
1
Position
178094104-178484147
Supporting publications (n)
1
EVMP confidence score
0.40
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function (2)
Biological Process (3)
Reactome (7)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence9
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RASAL2 | PRKAA1 | Q13131 | S | 351 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AAPK1 | Q13131 | NGAP | Q9UJF2 | Yes | PhosphoSite | PhosphoSite:33563064 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CSNK1A1FAM83GFAM83HRASAL2SPATA46ZNF618 | A6ND36P48729Q5T0L3Q5T7W0Q6ZRV2Q9UJF2 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CSNK1A1FAM83GFAM83HRASAL2ZNF618 | A6ND36P48729Q5T7W0Q6ZRV2Q9UJF2 | 0:0:0:0:0 | hu.MAP2 | |||
| RASAL2RFFLSHC1SHC2 | P29353P98077Q8WZ73Q9UJF2 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient Centrifugation | Mass spectrometryWestern blotting | 1 | 27601599 |
Sequence, Structure & Domains
Sequences
Length
1,139
Mass
128,558
Sequence
MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJF2-1; Sequence=Displayed; Name=2; IsoId=Q9UJF2-2; Sequence=VSP_045777, VSP_045778
Alternative Sequence
1..4; MQTP -> MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL (in isoform 2); 590..596; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
17..36; Polar residues; 45..56; Basic residues; 73..87; Basic and acidic residues; 751..760; Polar residues; 803..818; Polar residues; 833..855; Basic and acidic residues; 916..928; Low complexity
Domain (FT)
41..158; PH; 149..267; C2; 343..551; Ras-GAP
Region
1..87; Disordered; 684..704; Disordered; 751..782; Disordered; 803..869; Disordered; 910..953; Disordered; 1116..1139; Disordered
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37324943 | Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. | Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. |