Protein detail
NGAP
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Protein symbol NGAP | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Protein Class
Plasma proteinsPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
nGAP
Gene Description
RAS protein activator like 2
Chromosome
1
Position
178094104-178484147
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RASAL2 | PRKAA1 | Q13131 | S | 351 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AAPK1 | Q13131 | NGAP | Q9UJF2 | Yes | No | No | PhosphoSite | PhosphoSite:33563064 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CSNK1A1FAM83GFAM83HRASAL2SPATA46ZNF618 | A6ND36P48729Q5T0L3Q5T7W0Q6ZRV2Q9UJF2 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CSNK1A1FAM83GFAM83HRASAL2ZNF618 | A6ND36P48729Q5T7W0Q6ZRV2Q9UJF2 | 0:0:0:0:0 | hu.MAP2 | |||
| RASAL2RFFLSHC1SHC2 | P29353P98077Q8WZ73Q9UJF2 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient Centrifugation | Mass spectrometryWestern blotting | 1 | 27601599 |
Sequence, Structure & Domains
Sequences
Length
1,139
Mass
128,558
Sequence
MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJF2-1; Sequence=Displayed; Name=2; IsoId=Q9UJF2-2; Sequence=VSP_045777, VSP_045778
Alternative Sequence
1..4; MQTP -> MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL (in isoform 2); 590..596; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
17..36; Polar residues; 45..56; Basic residues; 73..87; Basic and acidic residues; 751..760; Polar residues; 803..818; Polar residues; 833..855; Basic and acidic residues; 916..928; Low complexity
Domain (FT)
41..158; PH; 149..267; C2; 343..551; Ras-GAP
Region
1..87; Disordered; 684..704; Disordered; 751..782; Disordered; 803..869; Disordered; 910..953; Disordered; 1116..1139; Disordered