Protein detail
STML2
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)
Entry name STML2 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
HSPC108SLP-2
Gene Description
Stomatin like 2
Chromosome
9
Position
35099776-35103195
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificstomach 1Cell SpecificEarly spermatidsBlood Cell SpecificgdT-cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
Reactome (5)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence13
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| STOML2 | PRKCZ | Q05513 | S | 17 | phosphorylation | PhosphoSite | |
| STOML2 | LYN | P07948 | Y | 124 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STML2 | Q9UJZ1 | PLCG1 | P19174 | Yes | Yes | SIGNOR | SIGNOR:18641330 | |
| STML2 | Q9UJZ1 | LCK | P06239 | Yes | Yes | SIGNOR | SIGNOR:18641330 | |
| STML2 | Q9UJZ1 | ZAP70 | P43403 | Yes | Yes | SIGNOR | SIGNOR:18641330 | |
| STML2 | Q9UJZ1 | CD3E | P07766 | Yes | Yes | SIGNOR | SIGNOR:18641330 |
Sequence, Structure & Domains
Sequences
Length
356
Mass
38,534
Sequence
MLARAARGTGALLLRGSLLASGRAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPVPGTPDSLSSGSSRDVQGTDASLDEELDRVKMS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJZ1-1; Sequence=Displayed; Name=2; IsoId=Q9UJZ1-2; Sequence=VSP_054651
Alternative Sequence
149..193; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
329..343; Polar residues
Coiled Coil
215..252
Region
321..356; Disordered
Protein Families
Band 7/mec-2 family
Sequence Similarities
Belongs to the band 7/mec-2 family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No related sentences available |