Protein detail

STML2

Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)

Entry name
STML2
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
Protein classification
Predicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Synonym
HSPC108SLP-2
Gene Description
Stomatin like 2
Chromosome
9
Position
35099776-35103195
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificstomach 1Cell SpecificEarly spermatidsBlood Cell SpecificgdT-cell
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
STOML2PRKCZQ05513S17phosphorylationPhosphoSite
STOML2LYNP07948Y124phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling

6 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo

Regulatory Interaction Network

4 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
STML2Q9UJZ1PLCG1P19174YesYesNoSIGNORSIGNOR:18641330
STML2Q9UJZ1LCKP06239YesYesNoSIGNORSIGNOR:18641330
STML2Q9UJZ1ZAP70P43403YesYesNoSIGNORSIGNOR:18641330
STML2Q9UJZ1CD3EP07766YesYesNoSIGNORSIGNOR:18641330

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry3381133683732247538207106
Sequence, Structure & Domains

Sequences

Length
356
Mass
38,534
Sequence
MLARAARGTGALLLRGSLLASGRAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPVPGTPDSLSSGSSRDVQGTDASLDEELDRVKMS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJZ1-1; Sequence=Displayed; Name=2; IsoId=Q9UJZ1-2; Sequence=VSP_054651
Alternative Sequence
149..193; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
329..343; Polar residues
Coiled Coil
215..252
Region
321..356; Disordered
Protein Families
Band 7/mec-2 family
Sequence Similarities
Belongs to the band 7/mec-2 family.
Clinical Relevance