Protein detail
FBXL2
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Protein symbol FBXL2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FBL2FBL3
Gene Description
F-box and leucine rich repeat protein 2
Chromosome
3
Position
33277025-33403662
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificHepatocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Molecular Function
Mediation Categories
Immune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FBXL2 | GSK3B | P49841 | T | 404 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FBXL2 | Q9UKC9 | P85B | O00459 | Yes | No | Yes | LMPIDSIGNOR | LMPID:23604317SIGNOR:23604317 |
| COMPLEX:P62877_P63208_Q13616 | FBXL2 | Q9UKC9 | Yes | No | Yes | SIGNOR | SIGNOR:25721664 | |
| FBXL2 | Q9UKC9 | COMPLEX:P62877_P63208_Q13616 | Yes | Yes | No | SIGNOR | SIGNOR:22323446SIGNOR:22024926SIGNOR:26037928 | |
| FBXL2 | Q9UKC9 | COMPLEX:P62877_P63208_Q13618 | Yes | Yes | No | SIGNOR | SIGNOR:23604317 | |
| FBXL2 | Q9UKC9 | CCND2 | P30279 | Yes | No | Yes | SIGNOR | SIGNOR:22323446 |
| FBXL2 | Q9UKC9 | AURKB | Q96GD4 | Yes | No | Yes | HINTSIGNOR | HINT:23928698HINT:23370391SIGNOR:23370391 |
| FBXL2 | Q9UKC9 | CCND3 | P30281 | Yes | No | Yes | SIGNOR | SIGNOR:22024926 |
| FBX3 | Q9UK99 | FBXL2 | Q9UKC9 | Yes | No | Yes | InnateDBSIGNORBioGRID | BioGRID:27010866SIGNOR:25721664InnateDB:24123678 |
| FBXL2 | Q9UKC9 | NLRP3 | Q96P20 | Yes | No | Yes | InnateDBSIGNOR | InnateDB:26037928SIGNOR:26037928 |
| GSK3B | P49841 | FBXL2 | Q9UKC9 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23542741PhosphoSite:27010866 |
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SCF E3 ubiquitin ligase complexFBXL2 variant | CUL1FBXL2RBX1SKP1 | P62877P63208Q13616Q9UKC9 | 1:1:1:1 | ComplexPortal | intact:EBI-9993018PDB:1LDJ | 119615463323406914755292235427411552027734445249 |
| SCF E3 ubiquitin ligase complexFBXL20 variant | CUL1FBXL20RBX1SKP1 | P62877P63208Q13616Q96IG2 | 1:1:1:1 | ComplexPortal | intact:EBI-9027295PDB:1LDJ | 1196154633234069147552923473178815520277 |
| SCF E3 ubiquitin ligase complexFBXL21 variant | CUL1FBXL21PRBX1SKP1 | P62877P63208Q13616Q9UKT6 | 1:1:1:1 | ComplexPortal | intact:EBI-9024837PDB:1LDJ | 119615461552027714755292234528553323406934445249 |
| SCF E3 ubiquitin ligase complexFBXL22 variant | CUL1FBXL22RBX1SKP1 | P62877P63208Q13616Q6P050 | 1:1:1:1 | ComplexPortal | intact:EBI-9017804PDB:1LDJ | 119615463323406914755292229728771552027734445249 |
| Ubiquitin E3 ligase (Fbxl20Skp1Cul1) | CUL1FBXL2FBXL20SKP1 | P63208Q13616Q96IG2Q9UKC9 | 1:1:1:1 | Compleat | Compleat:HC1546 | 17803915 |
| nuclear ubiquitin ligase complex | AMN1CUL1CUL2FBXL15FBXL2FBXL20RBX1RNF7SKP1 | P62877P63208Q13616Q13617Q8IY45Q96IG2Q9H469Q9UBF6Q9UKC9 | 1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC716 | 14747994 |
| FBXL2FBXL20YPEL1YPEL3 | O60688P61236Q96IG2Q9UKC9 | 0:0:0:0 | hu.MAP2 | |||
| CUL1FBXL20 | Q13616Q96IG2 | 0:0 | Havugimana2012 | Havugimana2012:C_57 |
Sequence, Structure & Domains
Sequences
Length
423
Mass
47,062
Sequence
MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKC9-1; Sequence=Displayed; Name=2; IsoId=Q9UKC9-2; Sequence=VSP_044600
Alternative Sequence
132..199; Missing (in isoform 2)
3D Structural Models
Turn
36..38
Helix
10..14; 17..24; 29..35; 40..46; 49..51; 67..75; 93..102; 119..128; 145..154; 171..180; 197..206; 223..232; 249..258; 275..284; 301..310; 327..334; 337..341; 356..361; 381..390
Beta Strand
53..56; 82..84; 108..110; 134..136; 160..162; 185..188; 212..214; 238..240; 264..266; 290..292; 316..318; 345..347; 370..372; 395..397
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Repeat
61..87; LRR 1; 88..113; LRR 2; 114..139; LRR 3; 140..165; LRR 4; 166..191; LRR 5; 192..217; LRR 6; 218..243; LRR 7; 244..269; LRR 8; 270..295; LRR 9; 296..321; LRR 10; 322..350; LRR 11; 351..375; LRR 12; 376..401; LRR 13
Motif
420..423; CAAX motif
Domain (CC)
The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex.
Domain (FT)
9..55; F-box
Region
80..90; Interaction with Calmodulin