Protein detail
DP13A
DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
Protein symbol DP13A | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
Ensembl
Entrez Gene Symbol
Gene Synonym
APPL
Gene Description
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Chromosome
3
Position
57227726-57278105
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
Cellular Component
- GO:0001726 ruffle
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0010008 endosome membrane
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0031410 cytoplasmic vesicle
- GO:0031901 early endosome membrane
- GO:0032009 early phagosome
- GO:0044354 macropinosome
- GO:0070062 extracellular exosome
- GO:0097708 intracellular vesicle
- GO:0098793 presynapse
- GO:0098794 postsynapse
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| APPL1 | PRKACA | P17612 | S | 410 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| APPL1 | PRKCA | P17252 | S | 430 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| APPL1 | INS | P01308 | S | 401 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:24813896 |
| APPL1 | ADIPOQ | Q15848 | S | 401 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:24813896 |
| APPL1 | GSK3B | P49841 | S | 401 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:24025512 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAQR1 | Q96A54 | DP13A | Q9UKG1 | Yes | Yes | No | SIGNORHPRDHINTBioGRIDLit-BM-17 | BioGRID:23762377HINT:16622416Lit-BM-17:16622416HINT:23762377Lit-BM-17:23762377SIGNOR:16622416HPRD:16622416 |
| PAQR2 | Q86V24 | DP13A | Q9UKG1 | Yes | Yes | No | Lit-BM-17SIGNOR | Lit-BM-17:16622416SIGNOR:16622416 |
| DP13A | Q9UKG1 | STK11 | Q15831 | Yes | Yes | No | SIGNOR | SIGNOR:19520843 |
| KPCA | P17252 | DP13A | Q9UKG1 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:20095645 |
| KAPCA | P17612 | DP13A | Q9UKG1 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:29212031PhosphoSite:17765681 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AKT1-APPL1-HDAC3 complexinduced by IGF-1 | AKT1APPL1HDAC3 | O15379P31749Q9UKG1 | 0:0:0 | CORUM | CORUM:7406 | 29523594 |
| AR-AKT-APPL complex | AKT1APPL1AR | P10275P31749Q9UKG1 | 1:1:1 | CompleatCORUM | Compleat:HC671CORUM:2159 | 12621049 |
| APPL1BCAS3BNIP3LMASTLPHAF1WIPI2 | O60238Q96GX5Q9BSU1Q9H6U6Q9UKG1Q9Y4P8 | 0:0:0:0:0:0 | hu.MAP2 | |||
| APPL1CASP9 | P55211Q9UKG1 | 0:0 | KEGG-MEDICUS | |||
| APPL1MASTLPHAF1ZBTB16 | Q05516Q96GX5Q9BSU1Q9UKG1 | 0:0:0:0 | hu.MAP | |||
| APPL1 | Q9UKG1 | 2 | PDB | PDB:2elaPDB:2ej8 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
709
Mass
79,663
Sequence
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA
3D Structural Models
Turn
12..14; 268..270; 557..559
Helix
9..11; 16..66; 67..70; 81..110; 112..120; 122..151; 157..217; 220..257; 259..261; 360..374; 519..534; 568..570; 612..629; 634..643
Beta Strand
152..154; 262..265; 281..286; 298..305; 308..312; 320..324; 329..333; 339..345; 348..350; 354..356; 499..512; 542..555; 562..567; 571..577; 580..590; 600..610
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
645..667; Basic and acidic residues; 674..693; Polar residues; 700..709; Basic and acidic residues
Motif
403..414; F&H
Coiled Coil
215..259; 621..673
Domain (CC)
Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.; DOMAIN: The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.
Domain (FT)
3..268; BAR; 277..375; PH; 496..656; PID
Region
1..428; Required for RAB5A binding; 397..434; Disordered; 467..491; Disordered; 645..709; Disordered
Clinical Relevance
Disease Involvement
Diabetes mellitusDisease variant
Drugs
INSL3COMPOUND 6641[125I]INSL3 (HUMAN)RELAXIN-3TAMRLXNANOLUC-INSL3[33P]RELAXIN (HUMAN)INSL3 B CHAIN DIMER ANALOGUE 8RELAXINRELAXIN-1CYCLIC INSL3 B-CHAIN ANALOGUE 6A(4-24)(B7-24)H2(DES 1-8) A-CHAIN INSL3 ANALOGUEA(9-26)INSL3EUROPIUM-LABELLED INSL3A(C10/15S)INSL3INSL3 B-CHAIN ANALOGUEA(10-24)INSL3INSL3 [A(5-26):B(7-27)]RLF-(A11-B10)-ISOPEPTIDE AMIDEA26 (XA11-B10)A(&DELTA10/15C)INSL3
Antibody
Interaction Protein
ENSG00000054654ENSG00000077522ENSG00000100220ENSG00000110395ENSG00000123159ENSG00000123584ENSG00000127191ENSG00000135636ENSG00000136044ENSG00000142208ENSG00000144566ENSG00000146648ENSG00000151914ENSG00000159346ENSG00000171720
Interaction Count
15
Interaction Dataset
intact_biogridbiogrid_bioplexintact_biogrid_opencell_bioplex