Protein detail
CHIC2
Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia)
Protein symbol CHIC2 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
BTL
Gene Description
Cysteine rich hydrophobic domain 2
Chromosome
4
Position
54009789-54064605
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificbasal gangliaCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass Spectrometry | 1 | 36028467 |
Sequence, Structure & Domains
Sequences
Length
165
Mass
19,254
Sequence
MADFDEIYEEEEDEERALEEQLLKYSPDPVVVRGSGHVTVFGLSNKFESEFPSSLTGKVAPEEFKASINRVNSCLKKNLPVNVRWLLCGCLCCCCTLGCSMWPVICLSKRTRRSIEKLLEWENNRLYHKLCLHWRLSKRKCETNNMMEYVILIEFLPKTPIFRPD
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
88..106; CHIC motif (Cys-rich)
Coiled Coil
1..26
Protein Families
CHIC family
Sequence Similarities
Belongs to the CHIC family.